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    Sf3b6 splicing factor 3B, subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 66055, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sf3b6provided by MGI
    Official Full Name
    splicing factor 3B, subunit 6provided by MGI
    Primary source
    MGI:MGI:1913305
    See related
    Ensembl:ENSMUSG00000037361 AllianceGenome:MGI:1913305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf3b14; 0610009D07Rik; 6030419K15Rik
    Summary
    Predicted to enable mRNA binding activity. Acts upstream of or within blastocyst formation and mRNA splicing, via spliceosome. Located in nucleus. Is expressed in central nervous system; early conceptus; secondary oocyte; and sensory organ. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 55.9), bladder adult (RPKM 52.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sf3b6 in Genome Data Viewer
    Location:
    12 A1.1; 12 2.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4867608..4877659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4817608..4827659)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene quinone oxidoreductase PIG3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8478 Neighboring gene FK506 binding protein 1b Neighboring gene STARR-positive B cell enhancer ABC_E4023 Neighboring gene WD repeat and coiled coil containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of four genes required for mammalian blastocyst formation. Maserati M, et al. Zygote, 2014 Aug. PMID 23211737
    2. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sf3b14 is required for the blastocyst formation.
      Title: Identification of four genes required for mammalian blastocyst formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3B subunit 6
    Names
    SF3B 14 kDa subunit
    pre-mRNA branch site protein p14
    splicing factor 3B, 14 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025323.2 → NP_079599.1  splicing factor 3B subunit 6

      See identical proteins and their annotated locations for NP_079599.1

      Status: PROVISIONAL

      Source sequence(s)
      BC019535
      Consensus CDS
      CCDS25791.1
      UniProtKB/Swiss-Prot
      P59708, Q3U9T9
      UniProtKB/TrEMBL
      A0A1W2P7L7
      Related
      ENSMUSP00000043662.8, ENSMUST00000046207.9
      Conserved Domains (1) summary
      cd12241
      Location:17 → 93
      RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4867608..4877659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59708.1 GenPept UniProtKB/Swiss-Prot:P59708

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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