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    Oscp1 organic solute carrier partner 1 [ Mus musculus (house mouse) ]

    Gene ID: 230751, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Oscp1provided by MGI
    Official Full Name
    organic solute carrier partner 1provided by MGI
    Primary source
    MGI:MGI:1916308
    See related
    Ensembl:ENSMUSG00000042616 AllianceGenome:MGI:1916308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730415O04; 1810007P19Rik; 6030436A01Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in cytoplasm. Is expressed in several structures, including brain ventricle; heart ventricle; and olfactory epithelium. Orthologous to human OSCP1 (organic solute carrier partner 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 14.5), frontal lobe adult (RPKM 1.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Oscp1 in Genome Data Viewer
    Location:
    4 D2.2; 4 59.82 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125949436..125985988)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126055643..126092195)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32908 Neighboring gene colony stimulating factor 3 receptor Neighboring gene STARR-positive B cell enhancer ABC_E2121 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene STARR-positive B cell enhancer ABC_E3512 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene U7 snRNP-specific Sm-like protein LSM10 Neighboring gene serine/threonine kinase 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuronal expression, cytosolic localization, and developmental regulation of the organic solute carrier partner 1 in the mouse brain. Hiratsuka K, et al. Histochem Cell Biol, 2011 Mar. PMID 21331566
    2. Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1). Kobayashi Y, et al. Drug Metab Dispos, 2007 Jul. PMID 17446263
    3. Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma. Chen S, et al. J Cell Physiol, 2018 Jun. PMID 29227538
    4. Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. Kobayashi Y, et al. J Biol Chem, 2005 Sep 16. PMID 16006562
    5. Intratesticular localization of the organic solute carrier protein, OSCP1, in spermatogenic cells in mice. Hiratsuka K, et al. Mol Reprod Dev, 2008 Oct. PMID 18324622

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abberant expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma
      Title: Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
    2. The results indicate that OSCP1 may have a role in the brain indirectly mediating substrate uptake into the neurons in adult animals.
      Title: Neuronal expression, cytosolic localization, and developmental regulation of the organic solute carrier partner 1 in the mouse brain.
    3. mouse testis OSCP1 may indirectly mediate substrate uptake into meiotic and spermiogenic germ cells, within the cytosol.
      Title: Intratesticular localization of the organic solute carrier protein, OSCP1, in spermatogenic cells in mice.
    4. Report molecular cloning/functional characterization of Oscp1 from mouse testes.
      Title: Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein OSCP1
    Names
    organic solute carrier 1
    organic solute carrier protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356446.1 → NP_001343375.1  protein OSCP1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI853667, AK077909, AL627101
      Consensus CDS
      CCDS89827.1
      UniProtKB/TrEMBL
      A0ZV96
      Related
      ENSMUSP00000152196.2, ENSMUST00000143712.3
      Conserved Domains (1) summary
      pfam10188
      Location:18 → 199
      Oscp1; Organic solute transport protein 1

    2. NM_172701.3 → NP_766289.2  protein OSCP1 isoform 1

      See identical proteins and their annotated locations for NP_766289.2

      Status: VALIDATED

      Source sequence(s)
      AI853667, AK077909, AL627101
      Consensus CDS
      CCDS38879.1
      UniProtKB/Swiss-Prot
      Q8BHQ7, Q8BHW2
      UniProtKB/TrEMBL
      A2A8Y5
      Related
      ENSMUSP00000045241.5, ENSMUST00000035497.5
      Conserved Domains (1) summary
      pfam10188
      Location:18 → 189
      Oscp1; Organic solute transport protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      125949436..125985988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503034.4 → XP_006503097.1  protein OSCP1 isoform X1

      Conserved Domains (1) summary
      pfam10188
      Location:49 → 201
      Oscp1; Organic solute transport protein 1

    RNA

    1. XR_004941873.1 RNA Sequence

    2. XR_003954925.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHW2.1 GenPept UniProtKB/Swiss-Prot:Q8BHW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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