Sdhaf1 succinate dehydrogenase complex assembly factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdhaf1provided by MGI
Official Full Name: succinate dehydrogenase complex assembly factor 1provided by MGI
Primary source: MGI:MGI:1915582
See related: Ensembl:ENSMUSG00000074211 AllianceGenome:MGI:1915582
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyrm8; 0610010E21Rik
Summary: Predicted to be involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; gut gland; large intestine; and thymus. Human ortholog(s) of this gene implicated in mitochondrial complex II deficiency. Orthologous to human SDHAF1 (succinate dehydrogenase complex assembly factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.39 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30020834..30021800, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30321409..30322375, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH), implicating alteration in SDH activity as causative of the injury.
Title: Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

AW490662 (e-PCR)
- UniSTS:179548

AI430885 (e-PCR)
- UniSTS:159623

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial respiratory chain complex II assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex II assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex II assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate dehydrogenase assembly factor 1, mitochondrial

Names: LYR motif-containing protein 8; SDH assembly factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.