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    Cenpp centromere protein P [ Mus musculus (house mouse) ]

    Gene ID: 66336, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenppprovided by MGI
    Official Full Name
    centromere protein Pprovided by MGI
    Primary source
    MGI:MGI:1913586
    See related
    Ensembl:ENSMUSG00000021391 AllianceGenome:MGI:1913586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700022C02Rik; 4921518G09Rik
    Summary
    Predicted to be involved in CENP-A containing chromatin assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of inner kinetochore. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human CENPP (centromere protein P). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 2.2), limb E14.5 (RPKM 2.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpp in Genome Data Viewer
    Location:
    13 A5; 13 25.27 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49617501..49806457, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49464025..49652950, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene BICD cargo adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_34478 Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene asporin Neighboring gene STARR-seq mESC enhancer starr_34480 Neighboring gene osteomodulin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E8527 Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene isoleucyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein P
    Names
    CENP-P

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025495.4 → NP_079771.1  centromere protein P

      See identical proteins and their annotated locations for NP_079771.1

      Status: VALIDATED

      Source sequence(s)
      AC123954, AC160978
      Consensus CDS
      CCDS26501.1
      UniProtKB/Swiss-Prot
      Q52KM2, Q8C647, Q9CVW9, Q9CZ92, Q9D5U7
      UniProtKB/TrEMBL
      B2RVI6
      Related
      ENSMUSP00000021818.8, ENSMUST00000021818.9
      Conserved Domains (1) summary
      pfam13096
      Location:102 → 278
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49617501..49806457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247350.2 → XP_030103210.1  centromere protein P isoform X5

      Conserved Domains (1) summary
      pfam13096
      Location:1 → 138
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    2. XM_011244405.4 → XP_011242707.1  centromere protein P isoform X2

      Conserved Domains (1) summary
      pfam13096
      Location:102 → 187
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    3. XM_036158109.1 → XP_036014002.1  centromere protein P isoform X3

      Conserved Domains (1) summary
      pfam13096
      Location:102 → 187
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    4. XM_036158108.1 → XP_036014001.1  centromere protein P isoform X3

      Conserved Domains (1) summary
      pfam13096
      Location:102 → 187
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    5. XM_036158107.1 → XP_036014000.1  centromere protein P isoform X1

      Conserved Domains (1) summary
      pfam13096
      Location:102 → 187
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    6. XM_011244407.4 → XP_011242709.1  centromere protein P isoform X4

      Conserved Domains (1) summary
      pfam13096
      Location:102 → 187
      CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

    RNA

    1. XR_004938050.1 RNA Sequence

    2. XR_003950462.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ92.1 GenPept UniProtKB/Swiss-Prot:Q9CZ92

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