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    Osgepl1 O-sialoglycoprotein endopeptidase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 72085, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osgepl1provided by MGI
    Official Full Name
    O-sialoglycoprotein endopeptidase-like 1provided by MGI
    Primary source
    MGI:MGI:1919335
    See related
    Ensembl:ENSMUSG00000026096 AllianceGenome:MGI:1919335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610001M19Rik
    Summary
    Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Located in mitochondrion. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 8.1), liver E14 (RPKM 5.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osgepl1 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53352070..53365502)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53313356..53326343)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00911 Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene predicted gene 28777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:53370474-53370583 Neighboring gene ORM1-like 1 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_00913 Neighboring gene ankyrin and armadillo repeat containing pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2543 Neighboring gene asparagine synthetase domain containing 1 Neighboring gene Asnsd1 upstream reading frame Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel human gene containing ANK repeats and ARM domains. Occhi G, et al. Biochem Biophys Res Commun, 2004 May 21. PMID 15110750
    2. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Jenne DE, et al. Genes Chromosomes Cancer, 2003 Jun. PMID 12696059
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC13061

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N(6)-L-threonylcarbamoyladenine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N(6)-L-threonylcarbamoyladenine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
    Names
    N6-L-threonylcarbamoyladenine synthase
    O-sialoglycoprotein endopeptidase-like protein 1
    probable O-sialoglycoprotein endopeptidase 2
    probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
    probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
    t(6)A synthase
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1
    tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
    NP_001272768.1
    XP_006496353.1
    XP_030098969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285839.1 → NP_001272768.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_001272768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC153650, AK011265, BC030671, BY780319
      Consensus CDS
      CCDS14953.1
      UniProtKB/Swiss-Prot
      Q3UVG1, Q6PEB4, Q8BLB6, Q9D0N0
      Related
      ENSMUSP00000027265.4, ENSMUST00000027265.10
      Conserved Domains (3) summary
      TIGR03723
      Location:39 → 372
      T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD
      cl17037
      Location:40 → 338
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      cl22532
      Location:39 → 145
      Carbam_trans_N; Carbamoyltransferase N-terminus

    RNA

    1. NR_104360.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' splice site and lacks an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153650, BC030671, BY780319
      Related
      ENSMUST00000151296.8

    2. NR_104361.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153650, AK137332, BY780319
      Related
      ENSMUST00000135614.8

    3. NR_151661.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153650

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      53352070..53365502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496290.5 → XP_006496353.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG0533
      Location:1 → 245
      TsaD; tRNA A37 threonylcarbamoyltransferase TsaD [Translation, ribosomal structure and biogenesis]

    2. XM_030243109.2 → XP_030098969.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG0533
      Location:3 → 174
      TsaD; tRNA A37 threonylcarbamoyltransferase TsaD [Translation, ribosomal structure and biogenesis]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028091.3: Suppressed sequence

      Description
      NM_028091.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEB4.2 GenPept UniProtKB/Swiss-Prot:Q6PEB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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