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    Ttn titin [ Mus musculus (house mouse) ]

    Gene ID: 22138, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ttnprovided by MGI
    Official Full Name
    titinprovided by MGI
    Primary source
    MGI:MGI:98864
    See related
    Ensembl:ENSMUSG00000051747 AllianceGenome:MGI:98864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L56; mdm; shru; 1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; D330041I19Rik; D830007G01Rik
    Summary
    Enables ankyrin binding activity. Involved in heart development; regulation of relaxation of cardiac muscle; and somitogenesis. Acts upstream of or within several processes, including forward locomotion; heart development; and sarcomere organization. Located in M band and Z disc. Is expressed in several structures, including alimentary system; embryo mesenchyme; heart; lung; and musculature. Used to study autosomal recessive limb-girdle muscular dystrophy type 2J; dilated cardiomyopathy 1G; and tibial muscular dystrophy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 23.7), mammary gland adult (RPKM 4.5) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ttn in Genome Data Viewer
    Location:
    2 C3; 2 45.13 cM
    Exon count:
    350
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76534324..76812901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76703980..76982557, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04894 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 Neighboring gene predicted gene, 39860 Neighboring gene predicted gene, 57692 Neighboring gene STARR-seq mESC enhancer starr_04895 Neighboring gene coiled-coil domain containing 141 Neighboring gene STARR-seq mESC enhancer starr_04897 Neighboring gene STARR-seq mESC enhancer starr_04899 Neighboring gene STARR-seq mESC enhancer starr_04900 Neighboring gene STARR-seq mESC enhancer starr_04901 Neighboring gene predicted gene, 39861 Neighboring gene SEC14 and spectrin domains 1 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (3) 
    • Endonuclease-mediated (6)  1 citation
    • Spontaneous (1) 
    • Targeted (14)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables muscle alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural molecule activity conferring elasticity ISO
    Inferred from Sequence Orthology
    more info
     
    enables telethonin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within detection of muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within heart growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of relaxation of cardiac muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sarcomere organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sarcomerogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle myosin thick filament assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle thin filament assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somitogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within striated muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in I band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in I band ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of muscle myosin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in striated muscle thin filament ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    titin
    Names
    connectin
    NP_001372637.1
    NP_035782.3
    NP_082280.2
    XP_036016413.1
    XP_036016417.1
    XP_036016420.1
    XP_036016421.1
    XP_036016422.1
    XP_036016427.1
    XP_036016428.1
    XP_036016429.1
    XP_036016430.1
    XP_036016431.1
    XP_036016433.1
    XP_036016436.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385708.1NP_001372637.1  titin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928681, AL928721, AL928789
      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Related
      ENSMUSP00000097561.4, ENSMUST00000099981.10
      Conserved Domains (22) summary
      cd05747
      Location:3454534636
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:1155011841
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00060
      Location:1748517569
      FN3; Fibronectin type 3 domain
      smart00410
      Location:1445814522
      IG_like; Immunoglobulin like
      PHA03247
      Location:1170212305
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:253346
      PRK12323; DNA polymerase III subunit gamma/tau
      cd00063
      Location:2688926981
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3323733513
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1106211086
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1320713275
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:2018820190
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2414324224
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3355633645
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      NF033839
      Location:1214912512
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
      cl11960
      Location:2018820281
      Ig; Immunoglobulin domain
    2. NM_011652.3NP_035782.3  titin isoform N2-A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (N2-A) represents the longer transcript and encodes the longer isoform (N2-A).
      Source sequence(s)
      AK029024, AK081896, AK084709, AK084780, AK085832, AK132562, AK139762, AK157782, AL928721, AL928789, BB532149, BG795347
      Consensus CDS
      CCDS38154.1
      UniProtKB/Swiss-Prot
      A2ASS5, A2ASS6, A2ASS7
      UniProtKB/TrEMBL
      E9Q8N1
      Related
      ENSMUSP00000107477.3, ENSMUST00000111846.9
      Conserved Domains (13) summary
      cd00096
      Location:48864954
      Ig; Immunoglobulin domain
      cd05747
      Location:3260132692
      Ig5_Titin_like; M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins
      cd05748
      Location:2004220115
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:37573823
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:1554115625
      FN3; Fibronectin type 3 domain
      smart00220
      Location:3129431548
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:3058430663
      IG; Immunoglobulin
      smart00410
      Location:2732327405
      IG_like; Immunoglobulin like
      cd00063
      Location:2494525037
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:62656354
      I-set; Immunoglobulin I-set domain
      cd14104
      Location:3129331569
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam00047
      Location:1251312579
      ig; Immunoglobulin domain
      cl11960
      Location:2368523758
      Ig; Immunoglobulin domain
    3. NM_028004.2NP_082280.2  titin isoform N2-B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (N2-B) has multiple differences in the coding region compared to variant N2-A. The resulting isoform (N2-B) has the same N- and C-termini but is shorter compared to isoform N2-A.
      Source sequence(s)
      AK029024, AK081896, AK084709, AK084780, AK132562, AK157782, AL928721, AL928789, BB662000
      UniProtKB/TrEMBL
      A0A5K1VVQ1
      Conserved Domains (13) summary
      cd00096
      Location:2401224079
      Ig; Immunoglobulin domain
      cd05747
      Location:2602026111
      Ig5_Titin_like; M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins
      cd05748
      Location:1346113534
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:913979
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:89609044
      FN3; Fibronectin type 3 domain
      smart00220
      Location:2471324967
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:2074220824
      IG; Immunoglobulin
      smart00410
      Location:2400324082
      IG_like; Immunoglobulin like
      cd00063
      Location:1836418456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:2602426112
      I-set; Immunoglobulin I-set domain
      cd14104
      Location:2471224988
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam00047
      Location:59325998
      ig; Immunoglobulin domain
      cl11960
      Location:1710417177
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76534324..76812901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160538.1XP_036016431.1  titin isoform X10

      UniProtKB/TrEMBL
      A0A5K1VVQ1
      Related
      ENSMUSP00000011934.7, ENSMUST00000011934.13
      Conserved Domains (16) summary
      cd05747
      Location:2606626157
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:2597626710
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:90069090
      FN3; Fibronectin type 3 domain
      smart00410
      Location:59796043
      IG_like; Immunoglobulin like
      cd00063
      Location:1841018502
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:2475825034
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam07679
      Location:9461035
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:47284796
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1170911711
      Ig; Ig strand A [structural motif]
      cd05748
      Location:1566415745
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:2507725166
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1170911802
      Ig; Immunoglobulin domain
    2. XM_036160537.1XP_036016430.1  titin isoform X9

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (19) summary
      cd05747
      Location:3237232463
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:3228233016
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1531215396
      FN3; Fibronectin type 3 domain
      smart00409
      Location:1228512349
      IG; Immunoglobulin
      smart00410
      Location:1112711191
      IG_like; Immunoglobulin like
      cd00063
      Location:2471624808
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3106431340
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1053510559
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1103411102
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1801518017
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2197022051
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3138331472
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1801518108
      Ig; Immunoglobulin domain
    3. XM_036160536.1XP_036016429.1  titin isoform X8

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (18) summary
      cd05747
      Location:3284332934
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:3275333487
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1578315867
      FN3; Fibronectin type 3 domain
      smart00410
      Location:1275612820
      IG_like; Immunoglobulin like
      cd00063
      Location:2518725279
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3153531811
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1100611030
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1150511573
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1848618488
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2107021149
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3185431943
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1848618579
      Ig; Immunoglobulin domain
    4. XM_036160535.1XP_036016428.1  titin isoform X7

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (18) summary
      cd05747
      Location:3287332964
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1581315897
      FN3; Fibronectin type 3 domain
      smart00410
      Location:1278612850
      IG_like; Immunoglobulin like
      cd00063
      Location:2521725309
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3156531841
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1103611060
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1153511603
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1851618518
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2110021179
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3188431973
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1851618609
      Ig; Immunoglobulin domain
    5. XM_036160534.1XP_036016427.1  titin isoform X6

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (19) summary
      cd05747
      Location:3289932990
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1583915923
      FN3; Fibronectin type 3 domain
      smart00409
      Location:1281212876
      IG; Immunoglobulin
      smart00410
      Location:1165411718
      IG_like; Immunoglobulin like
      cd00063
      Location:2524325335
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3159131867
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1106211086
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1156111629
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1854218544
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2112621205
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3191031999
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1854218635
      Ig; Immunoglobulin domain
    6. XM_036160529.1XP_036016422.1  titin isoform X5

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (19) summary
      cd05747
      Location:3301233103
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1595216036
      FN3; Fibronectin type 3 domain
      smart00409
      Location:1292512989
      IG; Immunoglobulin
      smart00410
      Location:1176711831
      IG_like; Immunoglobulin like
      cd00063
      Location:2535625448
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3170431980
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1106211086
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1167411742
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1865518657
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2261022691
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3202332112
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1865518748
      Ig; Immunoglobulin domain
    7. XM_036160528.1XP_036016421.1  titin isoform X4

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (19) summary
      cd05747
      Location:3321633307
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1615616240
      FN3; Fibronectin type 3 domain
      smart00410
      Location:1312913193
      IG_like; Immunoglobulin like
      COG0810
      Location:1106511134
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd00063
      Location:2556025652
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3190832184
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1106211086
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1187811946
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1885918861
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2281422895
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3222732316
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1885918952
      Ig; Immunoglobulin domain
    8. XM_036160527.1XP_036016420.1  titin isoform X3

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (20) summary
      cd05747
      Location:3337433465
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1631416398
      FN3; Fibronectin type 3 domain
      smart00409
      Location:1328713351
      IG; Immunoglobulin
      smart00410
      Location:1212912193
      IG_like; Immunoglobulin like
      COG0810
      Location:1106511134
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd00063
      Location:2571825810
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3206632342
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1106211086
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1203612104
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1901719019
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2297223053
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3238532474
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1901719110
      Ig; Immunoglobulin domain
    9. XM_036160524.1XP_036016417.1  titin isoform X2

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (19) summary
      cd05747
      Location:3340233493
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1634216426
      FN3; Fibronectin type 3 domain
      smart00410
      Location:1331513379
      IG_like; Immunoglobulin like
      COG0810
      Location:1106511134
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd00063
      Location:2574625838
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3209432370
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1106211086
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1206412132
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1904519047
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2300023081
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3241332502
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1904519138
      Ig; Immunoglobulin domain
    10. XM_036160520.1XP_036016413.1  titin isoform X1

      UniProtKB/TrEMBL
      A0A5K1VVQ9
      Conserved Domains (21) summary
      cd05747
      Location:3424934340
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:1020810736
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:1718917273
      FN3; Fibronectin type 3 domain
      smart00410
      Location:1416214226
      IG_like; Immunoglobulin like
      PHA03247
      Location:1178612205
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:253346
      PRK12323; DNA polymerase III subunit gamma/tau
      cd00063
      Location:2659326685
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:3294133217
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam02818
      Location:1230312329
      PPAK; PPAK motif
      pfam07679
      Location:72847373
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:1291112979
      Ig_3; Immunoglobulin domain
      pfam18362
      Location:95919621
      THB; Tri-helix bundle domain
      cd00096
      Location:1989219894
      Ig; Ig strand A [structural motif]
      cd05748
      Location:2384723928
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:3326033349
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      NF033839
      Location:1157111977
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
      cl11960
      Location:1989219985
      Ig; Immunoglobulin domain
    11. XM_036160540.1XP_036016433.1  titin isoform X11

      UniProtKB/TrEMBL
      A0A5K1VVQ1
      Conserved Domains (12) summary
      cd05747
      Location:2182921920
      IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      PTZ00121
      Location:2173922473
      PTZ00121; MAEBL; Provisional
      smart00060
      Location:47694853
      FN3; Fibronectin type 3 domain
      smart00410
      Location:17421806
      IG_like; Immunoglobulin like
      cd00063
      Location:1417314265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14104
      Location:2052120797
      STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
      pfam07679
      Location:2245722546
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:491559
      Ig_3; Immunoglobulin domain
      cd00096
      Location:74727474
      Ig; Ig strand A [structural motif]
      cd05748
      Location:1142711508
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd20927
      Location:2084020929
      IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
      cl11960
      Location:74727565
      Ig; Immunoglobulin domain
    12. XM_036160543.1XP_036016436.1  titin isoform X12

      Related
      ENSMUSP00000097560.4, ENSMUST00000099980.10
      Conserved Domains (9) summary
      PHA03307
      Location:242378
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam07679
      Location:9461035
      I-set; Immunoglobulin I-set domain
      pfam09042
      Location:465504
      Titin_Z; Titin Z
      pfam13927
      Location:35083589
      Ig_3; Immunoglobulin domain
      cd00096
      Location:32453247
      Ig; Ig strand A [structural motif]
      cd20951
      Location:20842175
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cd20972
      Location:103193
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cd20974
      Location:698
      IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:32453335
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027369.1: Suppressed sequence

      Description
      NM_027369.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.