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    Fbxw2 F-box and WD-40 domain protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 30050, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxw2provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 2provided by MGI
    Primary source
    MGI:MGI:1353435
    See related
    Ensembl:ENSMUSG00000035949 AllianceGenome:MGI:1353435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MD6; FBW2; Fwd2; 2700071L08Rik
    Summary
    Located in cytoplasm. Is expressed in central nervous system; retina; and urinary system. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.5), bladder adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxw2 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34694185..34716229, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34804364..34826282, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene heat shock protein 5 Neighboring gene predicted gene, 53241 Neighboring gene STARR-seq mESC enhancer starr_04266 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Secondary structure analysis identifies a putative mouse protein demonstrating similarity to the repeat units found in CDC4, the G protein beta subunits and related proteins. Duff K, et al. DNA Seq, 1992. PMID 1296816
    2. Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance. Ren C, et al. Cell Death Differ, 2022 Feb. PMID 34465889, Free PMC Article
    3. Structure and expression of the gene encoding mouse F-box protein, Fwd2. Miura M, et al. Genomics, 1999 Nov 15. PMID 10585767
    4. The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Yin Y, et al. Proc Natl Acad Sci U S A, 2019 Oct 8. PMID 31548378, Free PMC Article
    5. Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Maruyama S, et al. Genomics, 2001 Dec. PMID 11735228

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitination of NF-kappaB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance.
      Title: Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 2
    Names
    F-box and WD-40 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164769.2 → NP_001158241.1  F-box/WD repeat-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001158241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the 3' exon, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (2) is C-terminal truncated, compared to isoform 1.
      Source sequence(s)
      AL929106
      Consensus CDS
      CCDS50574.1
      UniProtKB/Swiss-Prot
      E9PXP3, Q60584
      UniProtKB/TrEMBL
      Q8BS25
      Related
      ENSMUSP00000108698.2, ENSMUST00000113075.8
      Conserved Domains (4) summary
      smart00256
      Location:60 → 94
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:140 → 359
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151 → 185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:140 → 354
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001164770.2 → NP_001158242.1  F-box/WD repeat-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001158242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' region, resulting in a downstream in-frame AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL929106
      Consensus CDS
      CCDS50573.1
      UniProtKB/TrEMBL
      A2AUF9
      Related
      ENSMUSP00000088541.4, ENSMUST00000091020.10
      Conserved Domains (2) summary
      sd00039
      Location:22 → 56
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11 → 318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001164772.2 → NP_001158244.1  F-box/WD repeat-containing protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001158244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several 3' exons, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q99L53, Q9CPQ6
      Conserved Domains (4) summary
      smart00256
      Location:60 → 94
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:142 → 236
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151 → 185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:140 → 232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001379115.2 → NP_001366044.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUF9
      Conserved Domains (2) summary
      sd00039
      Location:22 → 56
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11 → 318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_001379116.2 → NP_001366045.1  F-box/WD repeat-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Conserved Domains (2) summary
      sd00039
      Location:22 → 56
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11 → 286
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. NM_001379117.2 → NP_001366046.1  F-box/WD repeat-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q8CCH8
      Conserved Domains (3) summary
      smart00256
      Location:60 → 94
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151 → 185
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:140 → 415
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. NM_001379118.2 → NP_001366047.1  F-box/WD repeat-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Conserved Domains (3) summary
      smart00256
      Location:60 → 94
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151 → 185
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:140 → 280
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. NM_001406267.1 → NP_001393196.1  F-box/WD repeat-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL929106

    9. NM_001406268.1 → NP_001393197.1  F-box/WD repeat-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL929106

    10. NM_001406269.1 → NP_001393198.1  F-box/WD repeat-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q9QUH1
      Related
      ENSMUSP00000028220.4, ENSMUST00000028220.10

    11. NM_001406270.1 → NP_001393199.1  F-box/WD repeat-containing protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Related
      ENSMUSP00000108700.2, ENSMUST00000113077.8

    12. NM_001406271.1 → NP_001393200.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUF9

    13. NM_001406272.1 → NP_001393201.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUF9

    14. NM_001406273.1 → NP_001393202.1  F-box/WD repeat-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL929106

    15. NM_001406274.1 → NP_001393203.1  F-box/WD repeat-containing protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL929106

    16. NM_001406275.1 → NP_001393204.1  F-box/WD repeat-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q9CPQ6

    17. NM_001406276.1 → NP_001393205.1  F-box/WD repeat-containing protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Related
      ENSMUST00000134323.2

    18. NM_001406277.1 → NP_001393206.1  F-box/WD repeat-containing protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Related
      ENSMUST00000156130.2

    19. NM_001406278.1 → NP_001393207.1  F-box/WD repeat-containing protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL929106

    20. NM_001406279.1 → NP_001393208.1  F-box/WD repeat-containing protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL929106

    21. NM_013890.5 → NP_038918.3  F-box/WD repeat-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_038918.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL929106
      Consensus CDS
      CCDS15952.1
      UniProtKB/TrEMBL
      Q8CCH8, Q9QUH1
      Related
      ENSMUSP00000108703.3, ENSMUST00000113080.9
      Conserved Domains (3) summary
      smart00256
      Location:60 → 94
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151 → 185
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:140 → 447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34694185..34716229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001164768.1: Suppressed sequence

      Description
      NM_001164768.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60584.2 GenPept UniProtKB/Swiss-Prot:Q60584

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools