Wdr4 WD repeat domain 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr4provided by MGI
Official Full Name: WD repeat domain 4provided by MGI
Primary source: MGI:MGI:1889002
See related: Ensembl:ENSMUSG00000024037 AllianceGenome:MGI:1889002
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wh; mWH; D530049K22Rik
Summary: Predicted to enable tRNA methyltransferase activator activity. Predicted to be involved in tRNA (guanine-N7)-methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and microcephaly, growth deficiency, seizures, and brain malformations. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 9.8), limb E14.5 (RPKM 7.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 16.56 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31713296..31738946, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31494322..31519985, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR4 protein deficiency would induces gammaH2AX protein level elevation, heterochromatin relaxation and DNA damage down-stream sequences, including p53 activation, caspase-mediated apoptotic pathway, and p21-mediated G2/M cell cycle arrest.
Title: Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts.
regulates FEN1's potential DNA cleavage threat near the site of replication
Title: Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wdr4 (e-PCR), detects polymorphism
- UniSTS:259672

Wdr4 (e-PCR), detects polymorphism
- UniSTS:259171

Wdr4 (e-PCR), detects polymorphism
- UniSTS:256633

AI415180 (e-PCR)
- UniSTS:160635

AI448349 (e-PCR)
- UniSTS:166046

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tRNA methyltransferase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in tRNA (guanine-N7)-methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA (guanine-N7)-methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA (m7G46) methyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of tRNA (m7G46) methyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA methyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Names: WD repeat-containing protein 4; WD40 repeat protein 4; protein Wuho homolog; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405110.1 → NP_001392039.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform b

Status: VALIDATED

Source sequence(s)

AC166172
NM_001405114.1 → NP_001392043.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

Status: VALIDATED

Source sequence(s)

AC166172
NM_001405117.1 → NP_001392046.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

Status: VALIDATED

Source sequence(s)

AC166172
NM_001405119.1 → NP_001392048.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

Status: VALIDATED

Source sequence(s)

AC166172
NM_001405120.1 → NP_001392049.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

Status: VALIDATED

Source sequence(s)

AC166172
NM_021322.3 → NP_067297.2 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform a

See identical proteins and their annotated locations for NP_067297.2

Status: VALIDATED

Source sequence(s)

AC166172

Consensus CDS

CCDS28606.2

UniProtKB/TrEMBL

A0A494B9R5, E9Q156

Related

ENSMUSP00000126061.2, ENSMUST00000171171.9

Conserved Domains (3) summary

COG2319
Location:187 → 362

WD40; WD40 repeat [General function prediction only]

sd00039
Location:110 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:60 → 272

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

31713296..31738946 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160713.1 → XP_036016606.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006524715.5 → XP_006524778.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1

See identical proteins and their annotated locations for XP_006524778.1

UniProtKB/TrEMBL

A0A494B9R5, E9Q156

Conserved Domains (3) summary

COG2319
Location:187 → 362

WD40; WD40 repeat [General function prediction only]

sd00039
Location:110 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:60 → 272

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036160712.1 → XP_036016605.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006524719.5 → XP_006524782.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

See identical proteins and their annotated locations for XP_006524782.1

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006524724.3 → XP_006524787.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

See identical proteins and their annotated locations for XP_006524787.1

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011246553.4 → XP_011244855.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

See identical proteins and their annotated locations for XP_011244855.1

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030249934.2 → XP_030105794.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006524716.5 → XP_006524779.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1

See identical proteins and their annotated locations for XP_006524779.1

UniProtKB/TrEMBL

A0A494B9R5, E9Q156

Conserved Domains (3) summary

COG2319
Location:187 → 362

WD40; WD40 repeat [General function prediction only]

sd00039
Location:110 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:60 → 272

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006524723.4 → XP_006524786.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

See identical proteins and their annotated locations for XP_006524786.1

Conserved Domains (2) summary

sd00039
Location:6 → 42

7WD40; WD40 repeat [structural motif]

cl29593
Location:33 → 128

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...