Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ART1 ADP-ribosyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 417, updated on 27-Nov-2024

    Summary

    Official Symbol
    ART1provided by HGNC
    Official Full Name
    ADP-ribosyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:723
    See related
    Ensembl:ENSG00000129744 MIM:601625; AllianceGenome:HGNC:723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RT6; ART2; ARTC1; CD296
    Summary
    ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ART1 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3645128..3664416)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3690584..3729789)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3666358..3685646)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3662929-3663642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3081 Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC133217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein-arginine ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Names
    ADP-ribosyltransferase 2
    ADP-ribosyltransferase C2 and C3 toxin-like 1
    mono(ADP-ribosyl)transferase 1
    NP_004305.2
    XP_011518416.1
    XP_016873252.1
    XP_054224799.1
    XP_054224800.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004314.3NP_004305.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_004305.2

      Status: REVIEWED

      Source sequence(s)
      AC060812, BC069102, S74683
      Consensus CDS
      CCDS7744.1
      UniProtKB/Swiss-Prot
      P52961, Q6NTD2, Q96KT9
      Related
      ENSP00000250693.1, ENST00000250693.2
      Conserved Domains (1) summary
      pfam01129
      Location:39274
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      3645128..3664416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017763.3XP_016873252.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      P52961, Q6NTD2, Q96KT9
      Conserved Domains (1) summary
      pfam01129
      Location:39274
      ART; NAD:arginine ADP-ribosyltransferase
    2. XM_011520114.4XP_011518416.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011518416.1

      UniProtKB/Swiss-Prot
      P52961, Q6NTD2, Q96KT9
      Conserved Domains (1) summary
      pfam01129
      Location:39274
      ART; NAD:arginine ADP-ribosyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      3690584..3729789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368825.1XP_054224800.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    2. XM_054368824.1XP_054224799.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1