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    TMEM205 transmembrane protein 205 [ Homo sapiens (human) ]

    Gene ID: 374882, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM205provided by HGNC
    Official Full Name
    transmembrane protein 205provided by HGNC
    Primary source
    HGNC:HGNC:29631
    See related
    Ensembl:ENSG00000105518 MIM:613771; AllianceGenome:HGNC:29631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ501
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 32.8), thyroid (RPKM 28.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM205 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11342778..11346492, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11469756..11473392, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11453454..11456944, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetraspanin 16 Neighboring gene uncharacterized HSPC102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14008 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11456465-11457295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11461146-11461646 Neighboring gene coiled-coil domain containing 159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11467020-11467961 Neighboring gene phospholipid phosphatase related 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Targeting TMEM205 mediated drug resistance in ovarian clear cell carcinoma using oncolytic virus. Saini U, et al. J Ovarian Res, 2022 Dec 7. PMID 36476493, Free PMC Article
    2. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. Shen DW, et al. J Cell Physiol, 2010 Nov. PMID 20589834, Free PMC Article
    3. A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion. Gallenito MJ, et al. Metallomics, 2020 Oct 21. PMID 32789331, Free PMC Article
    4. The association of transporter genes polymorphisms and lung cancer chemotherapy response. Wang Y, et al. PLoS One, 2014. PMID 24643204, Free PMC Article
    5. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion.
      Title: A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion.
    2. The genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.
      Title: The association of transporter genes polymorphisms and lung cancer chemotherapy response.
    3. Results indicate that a novel mechanism for cisplatin resistance is mediated by TMEM205 overexpression.
      Title: Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3205, MGC110858

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 205
    Names
    MBC3205

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145416.2 → NP_001138888.1  transmembrane protein 205

      See identical proteins and their annotated locations for NP_001138888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      BC091472, BE889078
      Consensus CDS
      CCDS32909.1
      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000468733.1, ENST00000593256.6
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    2. NM_001321112.2 → NP_001308041.1  transmembrane protein 205

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AC024575, BQ639667, CB994930
      Consensus CDS
      CCDS32909.1
      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000466495.1, ENST00000588560.5
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    3. NM_001321113.2 → NP_001308042.1  transmembrane protein 205

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AC024575, BM352837, CB994930
      Consensus CDS
      CCDS32909.1
      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000466986.1, ENST00000586590.5
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    4. NM_001321114.2 → NP_001308043.1  transmembrane protein 205

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an internal segment in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      BM451378, CB994930
      Consensus CDS
      CCDS32909.1
      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000465553.1, ENST00000589555.5
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    5. NM_033408.4 → NP_212133.1  transmembrane protein 205

      See identical proteins and their annotated locations for NP_212133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      BC008365, BE889078
      Consensus CDS
      CCDS32909.1
      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000398258.1, ENST00000447337.5
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    6. NM_198536.3 → NP_940938.1  transmembrane protein 205

      See identical proteins and their annotated locations for NP_940938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      BC064948, BC091472, BE889078
      Consensus CDS
      CCDS32909.1
      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000346954.4, ENST00000354882.10
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11342778..11346492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451501.2 → XP_024307269.1  transmembrane protein 205 isoform X1

      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000465149.1, ENST00000587948.5
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    2. XM_024451500.2 → XP_024307268.1  transmembrane protein 205 isoform X1

      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    3. XM_005259899.3 → XP_005259956.1  transmembrane protein 205 isoform X1

      See identical proteins and their annotated locations for XP_005259956.1

      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
      Related
      ENSP00000465483.1, ENST00000586956.5
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 114
      DUF4149; Domain of unknown function (DUF4149)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11469756..11473392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320915.1 → XP_054176890.1  transmembrane protein 205 isoform X1

      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9

    2. XM_054320914.1 → XP_054176889.1  transmembrane protein 205 isoform X1

      UniProtKB/Swiss-Prot
      Q6UW68
      UniProtKB/TrEMBL
      K7ELQ9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UW68.1 GenPept UniProtKB/Swiss-Prot:Q6UW68

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