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    Rtn2 reticulon 2 (Z-band associated protein) [ Mus musculus (house mouse) ]

    Gene ID: 20167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rtn2provided by MGI
    Official Full Name
    reticulon 2 (Z-band associated protein)provided by MGI
    Primary source
    MGI:MGI:107612
    See related
    Ensembl:ENSMUSG00000030401 AllianceGenome:MGI:107612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ms10p; NSPLI; Nspl1; MMS10-P
    Summary
    Acts upstream of or within gene expression; intracellular protein transmembrane transport; and regulation of D-glucose import. Located in several cellular components, including T-tubule; Z disc; and terminal cisterna. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to human RTN2 (reticulon 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 67.1), heart adult (RPKM 42.8) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rtn2 in Genome Data Viewer
    Location:
    7 A3; 7 9.54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19016549..19030089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19282624..19296164)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vasodilator-stimulated phosphoprotein Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) Neighboring gene STARR-positive B cell enhancer ABC_E1082 Neighboring gene nuclear encoded tRNA selenocysteine 2 (anticodon TCA) Neighboring gene STARR-positive B cell enhancer ABC_E9021 Neighboring gene FBJ osteosarcoma oncogene B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nspl1, a new Z-band-associated protein. Geisler JG, et al. J Muscle Res Cell Motil, 1999 Oct. PMID 10672514
    2. Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. Ikemoto T, et al. Diabetes, 2009 Dec. PMID 19720795, Free PMC Article
    3. Molecular cloning of a novel mouse gene with predominant muscle and neural expression. Geisler JG, et al. Mamm Genome, 1998 Apr. PMID 9530622
    4. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. Liu Y, et al. J Biol Chem, 2008 Mar 7. PMID 18096700, Free PMC Article
    5. Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Laurén J, et al. Mol Cell Neurosci, 2003 Nov. PMID 14664809

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC35990

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gene expression IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of amyloid-beta formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in terminal cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reticulon-2
    Names
    NSP-like protein 1
    NSP-like protein I
    neuroendocrine-specific protein-like 1
    neuroendocrine-specific protein-like I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025364.3 → NP_001020535.1  reticulon-2 isoform C

      See identical proteins and their annotated locations for NP_001020535.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant B. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B.
      Source sequence(s)
      AK144271, AK160500, W65979
      Consensus CDS
      CCDS39797.1
      UniProtKB/TrEMBL
      Q3TUZ6, Q6IM74
      Related
      ENSMUSP00000104108.4, ENSMUST00000108468.5
      Conserved Domains (1) summary
      pfam02453
      Location:5 → 169
      Reticulon; Reticulon

    2. NM_013648.6 → NP_038676.1  reticulon-2 isoform B

      See identical proteins and their annotated locations for NP_038676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) represents the longer transcript and encodes the longer isoform (B).
      Source sequence(s)
      AK144271, AU066588, CJ176292
      Consensus CDS
      CCDS20896.1
      UniProtKB/Swiss-Prot
      O70620, O70622
      UniProtKB/TrEMBL
      Q6IM75
      Related
      ENSMUSP00000032559.10, ENSMUST00000032559.17
      Conserved Domains (2) summary
      pfam02453
      Location:272 → 436
      Reticulon; Reticulon
      pfam15552
      Location:106 → 248
      DUF4657; Domain of unknown function (DUF4657)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19016549..19030089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70622.1 GenPept UniProtKB/Swiss-Prot:O70622

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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