Krt72 keratin 72 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt72provided by MGI
Official Full Name: keratin 72provided by MGI
Primary source: MGI:MGI:2146034
See related: Ensembl:ENSMUSG00000056605 AllianceGenome:MGI:2146034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K72; CK-72; K6irs2; Krt2-35; Krt72-ps
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Is expressed in vibrissa. Orthologous to human KRT72 (keratin 72). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.02 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101684607..101694955, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101776172..101786520, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490783

AI507495 (e-PCR)
- UniSTS:165968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 72

Names: cytokeratin-72; keratin 72, pseudogene; keratin complex 2, basic, gene 35; type II inner root sheath-specific keratin-K6irs2; type-II keratin Kb35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213728.2 → NP_998893.1 keratin, type II cytoskeletal 72

See identical proteins and their annotated locations for NP_998893.1

Status: VALIDATED

Source sequence(s)

AA717861, AC104862, BK001584

Consensus CDS

CCDS27863.1

UniProtKB/Swiss-Prot

Q6IME9

Related

ENSMUSP00000065922.5, ENSMUST00000071104.6

Conserved Domains (4) summary

pfam00038
Location:133 → 446

Filament; Intermediate filament protein

pfam05098
Location:184 → 313

LEF-4; Late expression factor 4 (LEF-4)

pfam16208
Location:15 → 130

Keratin_2_head; Keratin type II head

cl09176
Location:300 → 429

FlgN; FlgN protein