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    Nek11 NIMA (never in mitosis gene a)-related expressed kinase 11 [ Mus musculus (house mouse) ]

    Gene ID: 208583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek11provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 11provided by MGI
    Primary source
    MGI:MGI:2442276
    See related
    Ensembl:ENSMUSG00000035032 AllianceGenome:MGI:2442276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932416N14Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitotic intra-S DNA damage checkpoint signaling; protein phosphorylation; and regulation of mitotic cell cycle phase transition. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cartilage; central nervous system; genitourinary system; and respiratory system. Orthologous to human NEK11 (NIMA related kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 3.4), lung adult (RPKM 0.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nek11 in Genome Data Viewer
    Location:
    9 F1; 9 56.61 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (105039355..105272723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105162156..105395524, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5099 Neighboring gene nudix hydrolase 16 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E895 Neighboring gene STARR-positive B cell enhancer ABC_E3856 Neighboring gene STARR-positive B cell enhancer ABC_E5100 Neighboring gene asteroid homolog 1 Neighboring gene ATPase, Ca++-sequestering Neighboring gene STARR-positive B cell enhancer mm9_chr9:105398187-105398487 Neighboring gene predicted gene, 40564 Neighboring gene STARR-seq mESC enhancer starr_25124 Neighboring gene STARR-seq mESC enhancer starr_25126 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek11
    Names
    NIMA-related kinase 11
    never in mitosis A-related kinase 11
    nimA-related protein kinase 11
    NP_766049.2
    XP_006511742.1
    XP_006511743.1
    XP_006511745.1
    XP_006511748.1
    XP_006511749.1
    XP_017168748.1
    XP_030100034.1
    XP_036010662.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172461.4 → NP_766049.2  serine/threonine-protein kinase Nek11

      See identical proteins and their annotated locations for NP_766049.2

      Status: VALIDATED

      Source sequence(s)
      AC113016, AC161250
      Consensus CDS
      CCDS23464.1
      UniProtKB/Swiss-Prot
      E9QNC3, Q8BLS6, Q8BW62, Q8C0Q4
      UniProtKB/TrEMBL
      Q0VDN9
      Related
      ENSMUSP00000038611.5, ENSMUST00000038648.11
      Conserved Domains (1) summary
      cd08222
      Location:29 → 288
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      105039355..105272723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154769.1 → XP_036010662.1  serine/threonine-protein kinase Nek11 isoform X7

      Conserved Domains (2) summary
      COG4913
      Location:63 → 191
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
      cl21453
      Location:1 → 63
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030244174.2 → XP_030100034.1  serine/threonine-protein kinase Nek11 isoform X7

      Conserved Domains (2) summary
      COG4913
      Location:63 → 191
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
      cl21453
      Location:1 → 63
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006511679.5 → XP_006511742.1  serine/threonine-protein kinase Nek11 isoform X1

      See identical proteins and their annotated locations for XP_006511742.1

      UniProtKB/Swiss-Prot
      E9QNC3, Q8BLS6, Q8BW62, Q8C0Q4
      UniProtKB/TrEMBL
      Q0VDN9
      Conserved Domains (1) summary
      cd08222
      Location:29 → 288
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    4. XM_006511682.4 → XP_006511745.1  serine/threonine-protein kinase Nek11 isoform X3

      UniProtKB/TrEMBL
      Q0VDN9
      Conserved Domains (1) summary
      cl21453
      Location:1 → 189
      PKc_like; Protein Kinases, catalytic domain

    5. XM_017313259.2 → XP_017168748.1  serine/threonine-protein kinase Nek11 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006511686.4 → XP_006511749.1  serine/threonine-protein kinase Nek11 isoform X6

      Conserved Domains (2) summary
      COG4913
      Location:75 → 203
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
      cl21453
      Location:5 → 75
      PKc_like; Protein Kinases, catalytic domain

    7. XM_006511680.1 → XP_006511743.1  serine/threonine-protein kinase Nek11 isoform X2

      UniProtKB/TrEMBL
      Q0VDN9
      Conserved Domains (1) summary
      cd08222
      Location:29 → 288
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    8. XM_006511685.2 → XP_006511748.1  serine/threonine-protein kinase Nek11 isoform X5

      UniProtKB/TrEMBL
      D3Z1E7
      Related
      ENSMUSP00000116864.2, ENSMUST00000140851.3
      Conserved Domains (1) summary
      cd08222
      Location:29 → 288
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    RNA

    1. XR_003947831.1 RNA Sequence

    2. XR_379760.1 RNA Sequence

    3. XR_379761.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0Q4.2 GenPept UniProtKB/Swiss-Prot:Q8C0Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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