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    Ces3b carboxylesterase 3B [ Mus musculus (house mouse) ]

    Gene ID: 13909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ces3bprovided by MGI
    Official Full Name
    carboxylesterase 3Bprovided by MGI
    Primary source
    MGI:MGI:3644960
    See related
    Ensembl:ENSMUSG00000062181 AllianceGenome:MGI:3644960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Es31; Ces3L; ES31L; Ces31L; Gm4738; EG13909
    Summary
    Predicted to enable carboxylesterase activity. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver adult (RPKM 134.0) See more
    Orthologs
    human all
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    Genomic context

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    See Ces3b in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105810365..105820561)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105083733..105093929)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2H Neighboring gene STARR-seq mESC enhancer starr_22519 Neighboring gene carboxylesterase 3A Neighboring gene STARR-positive B cell enhancer ABC_E5035 Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22521 Neighboring gene carboxylesterase 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver. Aida K, et al. Biochim Biophys Acta, 1993 Jul 18. PMID 7916639
    2. Mammalian carboxylesterase 3: comparative genomics and proteomics. Holmes RS, et al. Genetica, 2010 Jul. PMID 20422440, Free PMC Article
    3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 3B
    NP_001152887.1
    NP_653094.2
    XP_006530716.1
    XP_006530717.1
    XP_006530718.1
    XP_006530719.1
    XP_006530720.1
    XP_006530721.1
    XP_017168050.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159415.1 → NP_001152887.1  carboxylesterase 3B isoform 2 precursor

      See identical proteins and their annotated locations for NP_001152887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC164311, AI048193, AI173514, CA455872, CB946634, CB947075
      Consensus CDS
      CCDS52653.1
      UniProtKB/Swiss-Prot
      Q8VCU1
      Related
      ENSMUSP00000074004.7, ENSMUST00000074403.13
      Conserved Domains (2) summary
      COG0657
      Location:75 → 245
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:36 → 497
      COesterase; Carboxylesterase family

    2. NM_144511.2 → NP_653094.2  carboxylesterase 3B isoform 1 precursor

      See identical proteins and their annotated locations for NP_653094.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC164311, AI048193, AI173514, CA455872, CB946634, CB947075
      Consensus CDS
      CCDS22590.2
      UniProtKB/Swiss-Prot
      G5E8G7, G5E8K9, Q8VCU1, Q91XD5
      Related
      ENSMUSP00000090909.7, ENSMUST00000093221.13
      Conserved Domains (2) summary
      COG0657
      Location:75 → 245
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:36 → 547
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105810365..105820561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530654.4 → XP_006530717.1  carboxylesterase 3B isoform X2

      Conserved Domains (1) summary
      pfam00135
      Location:37 → 508
      COesterase; Carboxylesterase family

    2. XM_006530653.4 → XP_006530716.1  carboxylesterase 3B isoform X1

      Conserved Domains (1) summary
      pfam00135
      Location:37 → 520
      COesterase; Carboxylesterase family

    3. XM_006530655.4 → XP_006530718.1  carboxylesterase 3B isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:37 → 436
      COesterase; Carboxylesterase family

    4. XM_006530656.4 → XP_006530719.1  carboxylesterase 3B isoform X5

      Conserved Domains (1) summary
      pfam00135
      Location:37 → 435
      COesterase; Carboxylesterase family

    5. XM_006530657.4 → XP_006530720.1  carboxylesterase 3B isoform X6

      Conserved Domains (1) summary
      pfam00135
      Location:37 → 375
      COesterase; Carboxylesterase family

    6. XM_006530658.4 → XP_006530721.1  carboxylesterase 3B isoform X7

      Conserved Domains (1) summary
      cl21494
      Location:44 → 348
      Abhydrolase; alpha/beta hydrolases

    7. XM_017312561.2 → XP_017168050.1  carboxylesterase 3B isoform X3

      Conserved Domains (1) summary
      pfam00135
      Location:2 → 489
      COesterase; Carboxylesterase family

    RNA

    1. XR_004934768.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCU1.2 GenPept UniProtKB/Swiss-Prot:Q8VCU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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