Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grin2aprovided by MGI
Official Full Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)provided by MGI
Primary source: MGI:MGI:95820
See related: Ensembl:ENSMUSG00000059003 AllianceGenome:MGI:95820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR2A; GluN2A; NMDAR2A; GluRepsilon1
Summary: Enables NMDA glutamate receptor activity and calcium channel activity. Involved in glutamate receptor signaling pathway and regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including cell surface; synaptic membrane; and synaptic vesicle. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 1.8) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 5.28 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (9385765..9813744, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (9567901..9996083, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crucial role of NR2A mediating the activation of satellite glial cells in the trigeminal ganglion contributes to orofacial inflammatory pain during TMJ inflammation.
Title: The crucial role of NR2A mediating the activation of satellite glial cells in the trigeminal ganglion contributes to orofacial inflammatory pain during TMJ inflammation.
Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology.
Title: Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology.
Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity.
Title: Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity.
Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome.
Title: Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome.
Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice.
Title: Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice.
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
Title: GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
GluN2A mediates ketamine-induced rapid antidepressant-like responses.
Title: GluN2A mediates ketamine-induced rapid antidepressant-like responses.
Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
Title: Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
Title: Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory.
Title: Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory.

Submit: New GeneRIF Correction See all GeneRIFs (129)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3042 (e-PCR)
- UniSTS:515631

D16Mit183 (e-PCR), detects polymorphism
- UniSTS:127815

D16Mit33 (e-PCR), detects polymorphism
- UniSTS:127869

Grin2a (e-PCR), detects polymorphism
- UniSTS:143261

D16Mit87 (e-PCR), detects polymorphism
- UniSTS:127923

NoName (e-PCR)
- UniSTS:224496

Grin2a (e-PCR), detects polymorphism
- UniSTS:531448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
contributes_to NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to calcium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
contributes_to extracellularly glutamate-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within directional locomotion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	TAS Traceable Author Statement more info	PubMed
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, plasma membrane to endosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to postsynaptic membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to lithium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within serotonin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within startle response	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2A

Names: N-methyl D-aspartate receptor subtype 2A; glutamate [NMDA] receptor subunit epsilon-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008170.4 → NP_032196.2 glutamate receptor ionotropic, NMDA 2A precursor

See identical proteins and their annotated locations for NP_032196.2

Status: VALIDATED

Source sequence(s)

AC121974, AC126022, AC154190, AC164163

Consensus CDS

CCDS27943.1

UniProtKB/Swiss-Prot

P35436

Related

ENSMUSP00000142900.2, ENSMUST00000199708.5

Conserved Domains (5) summary

cd06378
Location:32 → 392

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

COG0834
Location:458 → 541

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13718
Location:403 → 802

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:556 → 828

Lig_chan; Ligand-gated ion channel

pfam10565
Location:839 → 1464

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

9385765..9813744 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521795.5 → XP_006521858.1 glutamate receptor ionotropic, NMDA 2A isoform X1

Conserved Domains (3) summary

pfam00060
Location:556 → 717

Lig_chan; Ligand-gated ion channel

cd06378
Location:32 → 387

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cl21456
Location:403 → 723

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily