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    Gzmn granzyme N [ Mus musculus (house mouse) ]

    Gene ID: 245839, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gzmnprovided by MGI
    Official Full Name
    granzyme Nprovided by MGI
    Primary source
    MGI:MGI:2675494
    See related
    Ensembl:ENSMUSG00000015443 AllianceGenome:MGI:2675494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GrN
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptotic inflammatory response. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human GZMB (granzyme B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 22.5) See more
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    Genomic context

    See Gzmn in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56403243..56412069, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56165786..56174612, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene predicted gene, 57616 Neighboring gene predicted gene 8961 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene STARR-seq mESC enhancer starr_36793 Neighboring gene predicted gene, 57615

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in granzyme-mediated programmed cell death signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytolytic granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305808.2NP_001292737.1  granzyme N isoform 1 precursor

      See identical proteins and their annotated locations for NP_001292737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC091783
      Consensus CDS
      CCDS88673.1
      UniProtKB/TrEMBL
      Q76HN3
      Related
      ENSMUSP00000153137.2, ENSMUST00000225535.2
      Conserved Domains (2) summary
      smart00020
      Location:20195
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:21194
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_153052.3NP_694692.1  granzyme N isoform 2 precursor

      See identical proteins and their annotated locations for NP_694692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC091783
      Consensus CDS
      CCDS27145.1
      UniProtKB/TrEMBL
      Q920S1
      Related
      ENSMUSP00000015587.8, ENSMUST00000015587.9
      Conserved Domains (2) summary
      smart00020
      Location:20241
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:21244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56403243..56412069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519020.2XP_006519083.1  granzyme N isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:5228
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_017316021.2XP_017171510.1  granzyme N isoform X3

      Conserved Domains (1) summary
      cd00190
      Location:21114
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_017316020.1XP_017171509.1  granzyme N isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:21114
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...