Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfsf9provided by MGI
Official Full Name: tumor necrosis factor (ligand) superfamily, member 9provided by MGI
Primary source: MGI:MGI:1101058
See related: Ensembl:ENSMUSG00000035678 AllianceGenome:MGI:1101058
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly63l; 4-1BBL; Cd137l; 4-1BB-L
Summary: Enables tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within regulation of immature T cell proliferation in thymus. Located in plasma membrane. Is expressed in bone; connective tissue; hip; and metanephros. Orthologous to human TNFSF9 (TNF superfamily member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 3.6), limb E14.5 (RPKM 3.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.67 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57412113..57414757)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57105287..57107758)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke.
Title: Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke.
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.
Title: CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.
CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE[-/-] Mice Via Rab7-Mediated Autophagy.
Title: CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE(-/-) Mice Via Rab7-Mediated Autophagy.
Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
Title: Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells.
Title: 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells.
Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
Title: Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
Activation of 4-1BBL+ B cells with CD40 agonism and IFNgamma elicits potent immunity against glioblastoma.
Title: Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma.
The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity.
Title: The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity.
The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137(+) FOXP3(+) Regulatory CD4 T Cells.
Title: The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137(+) FOXP3(+) Regulatory CD4 T Cells.
CD137 negatively affects ""browning"" of white adipose tissue during cold exposure.
Title: CD137 negatively affects "browning" of white adipose tissue during cold exposure.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI848817 (e-PCR)
- UniSTS:181049

D17Mit252 (e-PCR), detects polymorphism
- UniSTS:128064

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor superfamily binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor superfamily binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytotoxic T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytotoxic T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytotoxic T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immature T cell proliferation in thymus	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 9

Names: 4-1BB ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.