CXCR3 C-X-C motif chemokine receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CXCR3provided by HGNC
Official Full Name: C-X-C motif chemokine receptor 3provided by HGNC
Primary source: HGNC:HGNC:4540
See related: Ensembl:ENSG00000186810 MIM:300574; AllianceGenome:HGNC:4540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
Summary: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Expression: Biased expression in lymph node (RPKM 6.3), spleen (RPKM 3.4) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq13.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (71615919..71618511, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (70049169..70051938, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (70835769..70838361, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of CXCR3 in Nervous System-Related Diseases.
Title: The Role of CXCR3 in Nervous System-Related Diseases.
The IFN-gamma-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.
Title: The IFN-γ-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.
Hyperactivation of beta-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.
Title: Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.
The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.
Title: The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.
CXCL9 and its Receptor CXCR3, an Important Link Between Inflammation and Cardiovascular Risks in RA Patients.
Title: CXCL9 and its Receptor CXCR3, an Important Link Between Inflammation and Cardiovascular Risks in RA Patients.
Role of CXCR3 in fibrotic tissue responses.
Title: Role of CXCR3 in fibrotic tissue responses.
IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways.
Title: IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways.
EBV-positive pyothorax-associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3.
Title: EBV-positive pyothorax-associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3.
Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
Title: Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
Clinical Significance of the Pre-Transplant CXCR3 and CCR6 Expression on T Cells In Kidney Graft Recipients.
Title: Clinical Significance of the Pre-Transplant CXCR3 and CCR6 Expression on T Cells In Kidney Graft Recipients.

Submit: New GeneRIF Correction See all GeneRIFs (291)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced upregulation of the CXCR3 and EMAP2 expression in human lung microvascular endothelial cells	PubMed
	env	HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells	PubMed
Nef	nef	HIV-1 Nef induces variable levels of CXCR3 downregulation in different cell types	PubMed
	nef	Significant increases in neuronal cell death resulting from HIV-1 Nef-induced upregulation of IP-10 is reduced by an antibody directed against human CXCR3, suggesting an interaction of CXCR3 with Nef	PubMed
Tat	tat	HIV-1 Tat can inhibit CXCR3-mediated functions by interfering with the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of chemokine (C-X-C motif) receptor 3 (CXCR3) in Vif-expression T cells	PubMed
Vpu	vpu	HIV-1 Vpu downregulates the cell surface expression of chemokine (C-X-C motif) receptor 3 (CXCR3, CD183)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47042 (e-PCR)
- UniSTS:71956

STS-X95876 (e-PCR)
- UniSTS:34617

PMC135988P3 (e-PCR)
- UniSTS:270789

PMC198541P1 (e-PCR)
- UniSTS:271858

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine binding	IDA Inferred from Direct Assay more info	PubMed
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 3

Names: G protein-coupled receptor 9; IP-10 receptor; Mig receptor; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; interferon-inducible protein 10 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029076.1 RefSeqGene

Range

5007..7599

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001142797.2 → NP_001136269.1 C-X-C chemokine receptor type 3 isoform 2

See identical proteins and their annotated locations for NP_001136269.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).

Source sequence(s)

AF469635, X95876

Consensus CDS

CCDS48135.1

UniProtKB/TrEMBL

A0A0S2Z3W5

Related

ENSP00000362795.4, ENST00000373691.4

Conserved Domains (1) summary

cd15180
Location:101 → 376

7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001504.2 → NP_001495.1 C-X-C chemokine receptor type 3 isoform 1

See identical proteins and their annotated locations for NP_001495.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as CXCR3-A). This isoform functions as a receptor for chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).

Source sequence(s)

X95876

Consensus CDS

CCDS14416.1

UniProtKB/Swiss-Prot

B2R982, O15185, P49682, Q7Z710, Q9P2T4, Q9P2T5

UniProtKB/TrEMBL

A0A0S2Z3W5

Related

ENSP00000362797.3, ENST00000373693.4

Conserved Domains (1) summary

cd15180
Location:54 → 329

7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

71615919..71618511 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017029436.2 → XP_016884925.1 C-X-C chemokine receptor type 3 isoform X5

UniProtKB/TrEMBL

A0A0S2Z3W9
XM_047442010.1 → XP_047297966.1 C-X-C chemokine receptor type 3 isoform X3

UniProtKB/TrEMBL

A0A0S2Z3W9
XM_005262257.4 → XP_005262314.1 C-X-C chemokine receptor type 3 isoform X4

UniProtKB/TrEMBL

A0A0S2Z3W9

Conserved Domains (1) summary

pfam00001
Location:84 → 218

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_005262256.4 → XP_005262313.1 C-X-C chemokine receptor type 3 isoform X2

UniProtKB/TrEMBL

A0A0S2Z3W5

Conserved Domains (1) summary

pfam00001
Location:84 → 328

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_017029435.2 → XP_016884924.1 C-X-C chemokine receptor type 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z3W5

Conserved Domains (1) summary

cd15180
Location:101 → 376

7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

70049169..70051938 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054326874.1 → XP_054182849.1 C-X-C chemokine receptor type 3 isoform X4

UniProtKB/TrEMBL

A0A0S2Z3W9
XM_054326872.1 → XP_054182847.1 C-X-C chemokine receptor type 3 isoform X2

UniProtKB/TrEMBL

A0A0S2Z3W5
XM_054326875.1 → XP_054182850.1 C-X-C chemokine receptor type 3 isoform X5

UniProtKB/TrEMBL

A0A0S2Z3W9
XM_054326873.1 → XP_054182848.1 C-X-C chemokine receptor type 3 isoform X3

UniProtKB/TrEMBL

A0A0S2Z3W9
XM_054326871.1 → XP_054182846.1 C-X-C chemokine receptor type 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z3W5