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    PRRC2B proline rich coiled-coil 2B [ Homo sapiens (human) ]

    Gene ID: 84726, updated on 10-Dec-2024

    Summary

    Official Symbol
    PRRC2Bprovided by HGNC
    Official Full Name
    proline rich coiled-coil 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:28121
    See related
    Ensembl:ENSG00000288701 MIM:619544; AllianceGenome:HGNC:28121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAT2L; BAT2L1; LQFBS-1; KIAA0515
    Summary
    Enables RNA binding activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 18.3), ovary (RPKM 17.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PRRC2B in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131373651..131500193)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143583138..143713087)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134249038..134375580)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134176375-134176876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134176877-134177376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20412 Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene ReSE screen-validated silencer GRCh37_chr9:134197285-134197821 Neighboring gene uncharacterized LOC105376299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134205514-134206468 Neighboring gene uncharacterized LOC105376300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134227487-134227988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134230857-134231474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134231475-134232090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134234556-134235172 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134248209-134248730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134248731-134249254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134269973-134270734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134271497-134272258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134276654-134277645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134284252-134284752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29189 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134311463-134312438 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134312439-134313412 Neighboring gene Sharpr-MPRA regulatory region 9532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134364584-134365084 Neighboring gene small nucleolar RNA, C/D box 62A Neighboring gene uncharacterized LOC124902290 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134375403-134376602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378091-134378958 Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378959-134379824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388206-134388706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388707-134389207 Neighboring gene uncharacterized LOC105376301 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134403902-134405101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134405807-134406720 Neighboring gene protein O-mannosyltransferase 1 Neighboring gene uridine-cytidine kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • KIAA0515, MGC10526, DKFZp781F05101, DKFZp781K12107

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation  

    General protein information

    Preferred Names
    protein PRRC2B
    Names
    HLA-B associated transcript 2-like
    HLA-B-associated transcript 2-like 1
    proline-rich coiled-coil protein 2B
    protein BAT2-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384818.1NP_001371747.1  protein PRRC2B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Consensus CDS
      CCDS48044.1
      UniProtKB/Swiss-Prot
      O60270, Q5JSZ5, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
      Related
      ENSP00000508005.1, ENST00000684596.1
      Conserved Domains (2) summary
      pfam03154
      Location:18662175
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1189
      BAT2_N; BAT2 N-terminus
    2. NM_001384821.1NP_001371750.1  protein PRRC2B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Conserved Domains (2) summary
      pfam03154
      Location:18652174
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1189
      BAT2_N; BAT2 N-terminus
    3. NM_001384822.1NP_001371751.1  protein PRRC2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Conserved Domains (2) summary
      pfam03154
      Location:18652154
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1189
      BAT2_N; BAT2 N-terminus
    4. NM_001384823.1NP_001371752.1  protein PRRC2B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Related
      ENSP00000508073.1, ENST00000682501.1
      Conserved Domains (1) summary
      pfam07001
      Location:1189
      BAT2_N; BAT2 N-terminus
    5. NM_013318.4NP_037450.2  protein PRRC2B isoform 1

      See identical proteins and their annotated locations for NP_037450.2

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Consensus CDS
      CCDS48044.1
      UniProtKB/Swiss-Prot
      O60270, Q5JSZ5, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
      Related
      ENSP00000508048.1, ENST00000683519.1
      Conserved Domains (2) summary
      pfam03154
      Location:18662175
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1189
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      131373651..131500193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      143583138..143713087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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