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    CDC26 cell division cycle 26 [ Homo sapiens (human) ]

    Gene ID: 246184, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CDC26provided by HGNC
    Official Full Name
    cell division cycle 26provided by HGNC
    Primary source
    HGNC:HGNC:17839
    See related
    Ensembl:ENSG00000176386 MIM:614533; AllianceGenome:HGNC:17839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC12; ANAPC12; C9orf17
    Summary
    The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 9.9), appendix (RPKM 9.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDC26 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113266992..113275572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125465832..125474426, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116029272..116037852, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 31 member 2 Neighboring gene FKBP prolyl isomerase family member 15 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:115949815-115951014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28835 Neighboring gene solute carrier family 31 member 1 Neighboring gene uncharacterized LOC107987119 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116036963-116037818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106320 Neighboring gene pre-mRNA splicing tri-snRNP complex factor PRPF4 Neighboring gene ring finger protein 183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Wang J, et al. Nat Struct Mol Biol, 2009 Sep. PMID 19668213, Free PMC Article
    2. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Zachariae W, et al. Science, 1996 Nov 15. PMID 8895471
    3. A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. Wu H, et al. Clin Genet, 2022 Jan. PMID 34595750
    4. LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. Masuda K, et al. PLoS One, 2015. PMID 25723520, Free PMC Article
    5. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Lim HJ, et al. Mol Cell Biol, 2013 Nov. PMID 23979597, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit CDC26
    Names
    CDC26 subunit of anaphase promoting complex
    anaphase-promoting complex subunit 12
    cell division cycle 26 homolog
    cell division cycle protein 26 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139286.4 → NP_644815.1  anaphase-promoting complex subunit CDC26

      See identical proteins and their annotated locations for NP_644815.1

      Status: REVIEWED

      Source sequence(s)
      AL449305, BC042534, BF244254, CA446805
      Consensus CDS
      CCDS6790.1
      UniProtKB/Swiss-Prot
      Q8NHZ8
      Related
      ENSP00000363322.3, ENST00000374206.4
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 34
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113266992..113275572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014575.2 → XP_016870064.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 34
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    2. XM_047423145.1 → XP_047279101.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8

    3. XM_017014573.2 → XP_016870062.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 34
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    4. XM_047423146.1 → XP_047279102.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8

    5. XM_047423144.1 → XP_047279100.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8

    6. XM_017014574.2 → XP_016870063.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 34
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      125465832..125474426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362600.1 → XP_054218575.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8

    2. XM_054362602.1 → XP_054218577.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8

    3. XM_054362601.1 → XP_054218576.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHZ8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHZ8.1 GenPept UniProtKB/Swiss-Prot:Q8NHZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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