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    IL31RA interleukin 31 receptor A [ Homo sapiens (human) ]

    Gene ID: 133396, updated on 3-Dec-2024

    Summary

    Official Symbol
    IL31RAprovided by HGNC
    Official Full Name
    interleukin 31 receptor Aprovided by HGNC
    Primary source
    HGNC:HGNC:18969
    See related
    Ensembl:ENSG00000164509 MIM:609510; AllianceGenome:HGNC:18969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17
    Summary
    The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL31RA in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (55839789..55922850)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (56668079..56751259)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (55147185..55218678)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene S-phase kinase-associated protein 1-like Neighboring gene DEAD-box helicase 4 Neighboring gene RNA, 5S ribosomal pseudogene 183 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:55098870-55099053 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr5:55198729-55199230 and GRCh37_chr5:55199231-55199730 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:55206646-55207845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:55218660-55219260 Neighboring gene interleukin 6 cytokine family signal transducer Neighboring gene CRISPRi-FlowFISH-validated IL6ST regulatory element GRCh37_chr5:55289559-55291877 Neighboring gene small nucleolar RNA U13 Neighboring gene IL6ST divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Amyloidosis, primary localized cutaneous, 2
    MedGen: C3151404 OMIM: 613955 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif modulates the expression of interleukin 31 receptor A (IL31RA) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125346

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to other organism IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glandular epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homeostatic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in macrophage differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in monocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of macrophage activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-31 receptor subunit alpha
    Names
    IL-31 receptor subunit alpha
    IL-31R subunit alpha
    class I cytokine receptor
    cytokine receptor-like 3
    gp130-like monocyte receptor
    soluble type I cytokine receptor CRL3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029436.2 RefSeqGene

      Range
      16570..88063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242636.2NP_001229565.1  interleukin-31 receptor subunit alpha isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008914
      Consensus CDS
      CCDS75245.1
      UniProtKB/TrEMBL
      A0A494C190
      Related
      ENSP00000297015.4, ENST00000297015.7
      Conserved Domains (3) summary
      smart00060
      Location:434514
      FN3; Fibronectin type 3 domain
      cd00063
      Location:136235
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:38132
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001242637.2NP_001229566.1  interleukin-31 receptor subunit alpha isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008914, AK297938, AY358740, AY499339
      Consensus CDS
      CCDS56365.1
      UniProtKB/TrEMBL
      A0A494C190
      Related
      ENSP00000351935.5, ENST00000359040.10
      Conserved Domains (3) summary
      smart00060
      Location:453533
      FN3; Fibronectin type 3 domain
      cd00063
      Location:155254
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:57151
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. NM_001242638.2NP_001229567.1  interleukin-31 receptor subunit alpha isoform 4 precursor

      See identical proteins and their annotated locations for NP_001229567.1

      Status: REVIEWED

      Source sequence(s)
      AC008914, AK297938, AY358740, AY499341, AY499342
      Consensus CDS
      CCDS56366.1
      UniProtKB/TrEMBL
      A0A494C190
      Related
      ENSP00000347047.4, ENST00000354961.8
      Conserved Domains (3) summary
      smart00060
      Location:434514
      FN3; Fibronectin type 3 domain
      cd00063
      Location:136235
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:38132
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. NM_001242639.2NP_001229568.1  interleukin-31 receptor subunit alpha isoform 5

      See identical proteins and their annotated locations for NP_001229568.1

      Status: REVIEWED

      Source sequence(s)
      AC008914
      Consensus CDS
      CCDS56367.1
      UniProtKB/TrEMBL
      A0A494C190
      Related
      ENSP00000427533.1, ENST00000490985.5
      Conserved Domains (2) summary
      smart00060
      Location:311391
      FN3; Fibronectin type 3 domain
      cd00063
      Location:13112
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. NM_001297570.3NP_001284499.1  interleukin-31 receptor subunit alpha isoform 6

      See identical proteins and their annotated locations for NP_001284499.1

      Status: REVIEWED

      Source sequence(s)
      AC008914
      Consensus CDS
      CCDS75244.1
      Related
      ENSP00000380048.2, ENST00000396836.6
      Conserved Domains (2) summary
      cd00063
      Location:155254
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:57151
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    6. NM_139017.7NP_620586.3  interleukin-31 receptor subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_620586.3

      Status: REVIEWED

      Source sequence(s)
      AC008914
      Consensus CDS
      CCDS3970.2
      UniProtKB/TrEMBL
      A0A494C190
      Related
      ENSP00000498630.1, ENST00000652347.2
      Conserved Domains (3) summary
      smart00060
      Location:453533
      FN3; Fibronectin type 3 domain
      cd00063
      Location:155254
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:59142
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      55839789..55922850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543142.3XP_011541444.1  interleukin-31 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_011541444.1

      UniProtKB/Swiss-Prot
      A6NIF8, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8NI17, Q8WYJ0
      UniProtKB/TrEMBL
      A0A494C190
      Conserved Domains (3) summary
      smart00060
      Location:421501
      FN3; Fibronectin type 3 domain
      cd00063
      Location:123222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:25119
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_047416701.1XP_047272657.1  interleukin-31 receptor subunit alpha isoform X4

    3. XM_047416700.1XP_047272656.1  interleukin-31 receptor subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A494C190
    4. XM_011543145.2XP_011541447.1  interleukin-31 receptor subunit alpha isoform X3

      Conserved Domains (2) summary
      smart00060
      Location:283363
      FN3; Fibronectin type 3 domain
      cd00063
      Location:284
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      56668079..56751259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351572.1XP_054207547.1  interleukin-31 receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      A6NIF8, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8NI17, Q8WYJ0
      UniProtKB/TrEMBL
      A0A494C190
    2. XM_054351575.1XP_054207550.1  interleukin-31 receptor subunit alpha isoform X4

    3. XM_054351573.1XP_054207548.1  interleukin-31 receptor subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A494C190
    4. XM_054351574.1XP_054207549.1  interleukin-31 receptor subunit alpha isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001297572.2: Suppressed sequence

      Description
      NM_001297572.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.