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    PRAM1 PML-RARA regulated adaptor molecule 1 [ Homo sapiens (human) ]

    Gene ID: 84106, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRAM1provided by HGNC
    Official Full Name
    PML-RARA regulated adaptor molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:30091
    See related
    Ensembl:ENSG00000133246 MIM:606466; AllianceGenome:HGNC:30091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRAM-1; PML-RAR
    Summary
    The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PRAM1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8490056..8502640, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8477638..8490223, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8554940..8567524, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8477814-8478314 Neighboring gene Sharpr-MPRA regulatory region 12836 Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8488918-8489781 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene Sharpr-MPRA regulatory region 689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10025 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8563393-8564079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8570689-8571189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8571229-8571815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8576283-8577173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8587561-8588060 Neighboring gene zinc finger protein 414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8590637-8591612 Neighboring gene uncharacterized LOC124904633 Neighboring gene myosin IF

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC39864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neutrophil degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    PML-RARA-regulated adapter molecule 1
    Names
    PML-RARA target gene encoding an Adaptor Molecule-1
    PRAM

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032152.5NP_115528.4  PML-RARA-regulated adapter molecule 1

      See identical proteins and their annotated locations for NP_115528.4

      Status: REVIEWED

      Source sequence(s)
      AC092298, AJ272324, AK308227, BC028012, DA350460
      Consensus CDS
      CCDS45954.2
      UniProtKB/Swiss-Prot
      Q8N6W7, Q96QH2
      Related
      ENSP00000408342.2, ENST00000423345.5
      Conserved Domains (2) summary
      pfam14603
      Location:577655
      hSH3; Helically-extended SH3 domain
      cl26464
      Location:56412
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      8490056..8502640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272502.3XP_005272559.1  PML-RARA-regulated adapter molecule 1 isoform X2

      Conserved Domains (1) summary
      pfam14603
      Location:582655
      hSH3; Helically-extended SH3 domain
    2. XM_011528353.3XP_011526655.1  PML-RARA-regulated adapter molecule 1 isoform X3

      Conserved Domains (1) summary
      pfam14603
      Location:584665
      hSH3; Helically-extended SH3 domain
    3. XM_011528352.3XP_011526654.1  PML-RARA-regulated adapter molecule 1 isoform X1

      Conserved Domains (1) summary
      pfam14603
      Location:584657
      hSH3; Helically-extended SH3 domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      8477638..8490223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322311.1XP_054178286.1  PML-RARA-regulated adapter molecule 1 isoform X2

    2. XM_054322312.1XP_054178287.1  PML-RARA-regulated adapter molecule 1 isoform X3

    3. XM_054322310.1XP_054178285.1  PML-RARA-regulated adapter molecule 1 isoform X1