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    POLRMT RNA polymerase mitochondrial [ Homo sapiens (human) ]

    Gene ID: 5442, updated on 3-Dec-2024

    Summary

    Official Symbol
    POLRMTprovided by HGNC
    Official Full Name
    RNA polymerase mitochondrialprovided by HGNC
    Primary source
    HGNC:HGNC:9200
    See related
    Ensembl:ENSG00000099821 MIM:601778; AllianceGenome:HGNC:9200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APOLMT; MTRNAP; MTRPOL; COXPD55; h-mtRPOL
    Summary
    This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 15.0), kidney (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POLRMT in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (617221..633537, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (571527..587843, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (617221..633537, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene MPRA-validated peak3211 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13565 Neighboring gene uncharacterized LOC107987266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13566 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:613339-613520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:629803-630486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9611 Neighboring gene uncharacterized LOC105372234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:638495-639220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:644145-645085 Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:657815-658727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:658728-659641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9615

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA primase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-directed 5'-3' RNA polymerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA polymerase I activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase III activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase IV activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase V activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitochondrial promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mitochondrial single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plastid single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in plastid transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase IV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase V IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation at mitochondrial promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial DNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA-directed RNA polymerase, mitochondrial
    Names
    polymerase (RNA) mitochondrial (DNA directed)
    NP_001394734.1
    NP_001394735.1
    NP_001394736.1
    NP_001394737.1
    NP_001394738.1
    NP_001394739.1
    NP_001394740.1
    NP_001394741.1
    NP_001394742.1
    NP_001394743.1
    NP_001394744.1
    NP_001394745.1
    NP_001394758.1
    NP_001394759.1
    NP_001394760.1
    NP_001394761.1
    NP_001394762.1
    NP_001394763.1
    NP_001394764.1
    NP_001394765.1
    NP_005026.3
    XP_047294907.1
    XP_054177217.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023049.1 RefSeqGene

      Range
      5032..21348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001407805.1NP_001394734.1  DNA-directed RNA polymerase, mitochondrial isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    2. NM_001407806.1NP_001394735.1  DNA-directed RNA polymerase, mitochondrial isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    3. NM_001407807.1NP_001394736.1  DNA-directed RNA polymerase, mitochondrial isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    4. NM_001407808.1NP_001394737.1  DNA-directed RNA polymerase, mitochondrial isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    5. NM_001407809.1NP_001394738.1  DNA-directed RNA polymerase, mitochondrial isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    6. NM_001407810.1NP_001394739.1  DNA-directed RNA polymerase, mitochondrial isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    7. NM_001407811.1NP_001394740.1  DNA-directed RNA polymerase, mitochondrial isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    8. NM_001407812.1NP_001394741.1  DNA-directed RNA polymerase, mitochondrial isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    9. NM_001407813.1NP_001394742.1  DNA-directed RNA polymerase, mitochondrial isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    10. NM_001407814.1NP_001394743.1  DNA-directed RNA polymerase, mitochondrial isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    11. NM_001407815.1NP_001394744.1  DNA-directed RNA polymerase, mitochondrial isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    12. NM_001407816.1NP_001394745.1  DNA-directed RNA polymerase, mitochondrial isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    13. NM_001407829.1NP_001394758.1  DNA-directed RNA polymerase, mitochondrial isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    14. NM_001407830.1NP_001394759.1  DNA-directed RNA polymerase, mitochondrial isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    15. NM_001407831.1NP_001394760.1  DNA-directed RNA polymerase, mitochondrial isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q59E91
    16. NM_001407832.1NP_001394761.1  DNA-directed RNA polymerase, mitochondrial isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q4G0F4
    17. NM_001407833.1NP_001394762.1  DNA-directed RNA polymerase, mitochondrial isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q59E91
    18. NM_001407834.1NP_001394763.1  DNA-directed RNA polymerase, mitochondrial isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q59E91
    19. NM_001407835.1NP_001394764.1  DNA-directed RNA polymerase, mitochondrial isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q59E91
    20. NM_001407836.1NP_001394765.1  DNA-directed RNA polymerase, mitochondrial isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC004449
      UniProtKB/TrEMBL
      Q59E91
    21. NM_005035.4NP_005026.3  DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

      See identical proteins and their annotated locations for NP_005026.3

      Status: REVIEWED

      Source sequence(s)
      AC004449, BC030829, BC070057, BC098387
      Consensus CDS
      CCDS12036.1
      UniProtKB/Swiss-Prot
      O00411, O60370
      UniProtKB/TrEMBL
      Q4G0F4
      Related
      ENSP00000465759.2, ENST00000588649.7
      Conserved Domains (3) summary
      sd00004
      Location:261290
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:8311229
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:432703
      RPOL_N; DNA-directed RNA polymerase N-terminal

    RNA

    1. NR_176425.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004449

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      617221..633537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438951.1XP_047294907.1  DNA-directed RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q4G0F4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      571527..587843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321242.1XP_054177217.1  DNA-directed RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q4G0F4