RAMAC RNA guanine-7 methyltransferase activating subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAMACprovided by HGNC
Official Full Name: RNA guanine-7 methyltransferase activating subunitprovided by HGNC
Primary source: HGNC:HGNC:31022
See related: Ensembl:ENSG00000169612 MIM:614547; AllianceGenome:HGNC:31022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAM; RAMMET; C15orf18; FAM103A1; HsT19360
Summary: Enables RNA binding activity and enzyme activator activity. Involved in 7-methylguanosine mRNA capping. Located in nucleus. Part of mRNA cap methyltransferase RNMT:RAMAC complex and mRNA capping enzyme complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q25.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (82986210..82991057)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (80850581..80855428)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (83654962..83659809)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of allosteric activation of human RNMT by RAM has been reported.
Title: Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations.
RNMT-RAM complex coordinates mRNA processing with ribosome production.
Title: c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production.
Data suggest that RAM/FAM103A1 has three domains: N-terminal activation domain (RAD); central RNA-binding domain (NR domain); and C-terminal nuclear localization domain (QYP) which contains two nuclear localization signal sequences.
Title: RAM function is dependent on Kapβ2-mediated nuclear entry.
RAM is an essential component of the core gene expression machinery
Title: RAM/Fam103a1 is required for mRNA cap methylation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65049 (e-PCR)
- UniSTS:86795

STS-N36410 (e-PCR)
- UniSTS:42529

RH64882 (e-PCR)
- UniSTS:84961

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA 5'-cap (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mRNA cap methyltransferase RNMT:RAMAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of mRNA capping enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mRNA capping enzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA guanine-N7 methyltransferase activating subunit

Names: RNMT activating mRNA cap methyltransferase subunit; RNMT-activating mini protein; family with sequence similarity 103 member A1; protein FAM103A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.