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    MSI1 musashi RNA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 4440, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MSI1provided by HGNC
    Official Full Name
    musashi RNA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:7330
    See related
    Ensembl:ENSG00000135097 MIM:603328; AllianceGenome:HGNC:7330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MSI1 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120339662..120369164, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120326839..120356341, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120779133..120806967, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120752165-120752348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120753363-120754138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7139 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7140 Neighboring gene phospholipase A2 group IB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120794238-120794738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796175-120796787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796788-120797399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120798696-120799414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120799415-120800132 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120803530-120803720 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120814267-120814767 Neighboring gene ribosomal protein S27 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7142 Neighboring gene Sharpr-MPRA regulatory region 12947 Neighboring gene MPRA-validated peak2004 silencer Neighboring gene MPRA-validated peak2005 silencer Neighboring gene MPRA-validated peak2007 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120876089-120876610 Neighboring gene uncharacterized LOC124903126 Neighboring gene cytochrome c oxidase subunit 6A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer. Wang X, et al. PLoS One, 2014. PMID 24787949, Free PMC Article
    2. Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome. El-Salhy M, et al. Mol Med Rep, 2020 Oct. PMID 32945509, Free PMC Article
    3. The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis. Vo DT, et al. Am J Pathol, 2012 Nov. PMID 22985791, Free PMC Article
    4. The expression patterns of Msi1 related with the glioma grade and the cytoplasmic Msi1 promotes angiogenesis. Song X, et al. Tissue Cell, 2013 Feb. PMID 23017339
    5. The effects of Hedgehog on the RNA-binding protein Msi1 in the proliferation and apoptosis of mesenchymal stem cells. Hong IS, et al. PLoS One, 2013. PMID 23418578, Free PMC Article

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
      Title: Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
    2. Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis.
      Title: Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis.
    3. Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
      Title: Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
    4. Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
      Title: Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
    5. The oncogene Musashi1 encodes novel miRNAs in breast cancer.
      Title: The oncogene Musashi1 encodes novel miRNAs in breast cancer.
    6. Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.
      Title: Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.
    7. Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1.
      Title: Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1.
    8. Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
      Title: Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
    9. The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma.
      Title: The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma.
    10. Immunolocalization of stem/progenitor cell biomarkers Oct-4, C-kit and Musashi-1 in endometriotic lesions.
      Title: Immunolocalization of stem/progenitor cell biomarkers Oct-4, C-kit and Musashi-1 in endometriotic lesions.
    Submit: New GeneRIF Correction See all GeneRIFs (98)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 1
    Names
    musashi-1
    musashi1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414485.1 → NP_001401414.1  RNA-binding protein Musashi homolog 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC003982

    2. NM_001414486.1 → NP_001401415.1  RNA-binding protein Musashi homolog 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC003982

    3. NM_001414487.1 → NP_001401416.1  RNA-binding protein Musashi homolog 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC003982

    4. NM_001414488.1 → NP_001401417.1  RNA-binding protein Musashi homolog 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC003982

    5. NM_001414489.1 → NP_001401418.1  RNA-binding protein Musashi homolog 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC003982

    6. NM_001414490.1 → NP_001401419.1  RNA-binding protein Musashi homolog 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC003982

    7. NM_001414491.1 → NP_001401420.1  RNA-binding protein Musashi homolog 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC003982

    8. NM_001414492.1 → NP_001401421.1  RNA-binding protein Musashi homolog 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC003982
      UniProtKB/TrEMBL
      H0YHB7
      Related
      ENSP00000446710.1, ENST00000546985.1

    9. NM_001414493.1 → NP_001401422.1  RNA-binding protein Musashi homolog 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC003982

    10. NM_001414494.1 → NP_001401423.1  RNA-binding protein Musashi homolog 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC003982

    11. NM_001414495.1 → NP_001401424.1  RNA-binding protein Musashi homolog 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC003982

    12. NM_001414496.1 → NP_001401425.1  RNA-binding protein Musashi homolog 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC003982

    13. NM_001414497.1 → NP_001401426.1  RNA-binding protein Musashi homolog 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC003982
      UniProtKB/TrEMBL
      H0YHB7

    14. NM_001414498.1 → NP_001401427.1  RNA-binding protein Musashi homolog 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC003982
      UniProtKB/TrEMBL
      H0YHB7

    15. NM_002442.4 → NP_002433.1  RNA-binding protein Musashi homolog 1 isoform a

      See identical proteins and their annotated locations for NP_002433.1

      Status: REVIEWED

      Source sequence(s)
      AB012851, AC003982, AI583233, BX393884
      Consensus CDS
      CCDS9196.1
      UniProtKB/Swiss-Prot
      O43347, Q96PU0, Q96PU1, Q96PU2, Q96PU3
      Related
      ENSP00000257552.2, ENST00000257552.7
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 339
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      120339662..120369164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538361.4 → XP_011536663.1  RNA-binding protein Musashi homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011536663.1

      UniProtKB/Swiss-Prot
      O43347, Q96PU0, Q96PU1, Q96PU2, Q96PU3
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 339
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    2. XM_047428872.1 → XP_047284828.1  RNA-binding protein Musashi homolog 1 isoform X4

      UniProtKB/TrEMBL
      H0YHB7

    3. XM_011538366.3 → XP_011536668.1  RNA-binding protein Musashi homolog 1 isoform X3

      See identical proteins and their annotated locations for XP_011536668.1

      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 236
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    4. XM_011538364.3 → XP_011536666.1  RNA-binding protein Musashi homolog 1 isoform X2

      Conserved Domains (2) summary
      COG0724
      Location:8 → 87
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12323
      Location:10 → 83
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    5. XM_006719404.4 → XP_006719467.1  RNA-binding protein Musashi homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_006719467.1

      UniProtKB/TrEMBL
      B3KN16
      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 201
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_011538371.3 → XP_011536673.1  RNA-binding protein Musashi homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_011536673.1

      UniProtKB/TrEMBL
      B3KN16
      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 201
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_011538368.3 → XP_011536670.1  RNA-binding protein Musashi homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_011536670.1

      UniProtKB/TrEMBL
      B3KN16
      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 201
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_011538370.3 → XP_011536672.1  RNA-binding protein Musashi homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_011536672.1

      UniProtKB/TrEMBL
      B3KN16
      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 201
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      120326839..120356341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372081.1 → XP_054228056.1  RNA-binding protein Musashi homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      O43347, Q96PU0, Q96PU1, Q96PU2, Q96PU3

    2. XM_054372084.1 → XP_054228059.1  RNA-binding protein Musashi homolog 1 isoform X4

      UniProtKB/TrEMBL
      H0YHB7

    3. XM_054372083.1 → XP_054228058.1  RNA-binding protein Musashi homolog 1 isoform X3

    4. XM_054372082.1 → XP_054228057.1  RNA-binding protein Musashi homolog 1 isoform X2

    5. XM_054372085.1 → XP_054228060.1  RNA-binding protein Musashi homolog 1 isoform X5

      UniProtKB/TrEMBL
      B3KN16

    6. XM_054372087.1 → XP_054228062.1  RNA-binding protein Musashi homolog 1 isoform X5

      UniProtKB/TrEMBL
      B3KN16

    7. XM_054372086.1 → XP_054228061.1  RNA-binding protein Musashi homolog 1 isoform X5

      UniProtKB/TrEMBL
      B3KN16

    8. XM_054372088.1 → XP_054228063.1  RNA-binding protein Musashi homolog 1 isoform X5

      UniProtKB/TrEMBL
      B3KN16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43347.1 GenPept UniProtKB/Swiss-Prot:O43347

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