Cdca8 cell division cycle associated 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdca8provided by MGI
Official Full Name: cell division cycle associated 8provided by MGI
Primary source: MGI:MGI:1196274
See related: Ensembl:ENSMUSG00000028873 AllianceGenome:MGI:1196274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BOR; DasraB; MESRGP; Borealin; D4Ertd421e; 4831429J16Rik
Summary: Predicted to be involved in mitotic metaphase chromosome alignment. Located in chromocenter. Is expressed in several structures, including central nervous system; early embryo; gonad; metanephros; and retina. Orthologous to human CDCA8 (cell division cycle associated 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 40.8), liver E14.5 (RPKM 38.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.93 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (124812258..124830710, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (124918465..124936917, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures.
Title: Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures.
These findings indicate that Borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that Borealin could be a potential target for related liver diseases.
Title: Hepatic Loss of Borealin Impairs Postnatal Liver Development, Regeneration, and Hepatocarcinogenesis.
Borealin plays a crucial role in the early mouse embryonic development
Title: Borealin is differentially expressed in ES cells and is essential for the early development of embryonic cells.
Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53
Title: Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU044747 (e-PCR)
- UniSTS:159284

RH127302 (e-PCR)
- UniSTS:167393

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic sister chromatid separation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	ISO Inferred from Sequence Orthology more info
part_of chromosome passenger complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: borealin

Names: MESrg; cell division cycle-associated protein 8; embryonic stem cell-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.