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    Slfn8 schlafen 8 [ Mus musculus (house mouse) ]

    Gene ID: 276950, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slfn8provided by MGI
    Official Full Name
    schlafen 8provided by MGI
    Primary source
    MGI:MGI:2672859
    See related
    Ensembl:ENSMUSG00000035208 AllianceGenome:MGI:2672859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mSLFN8
    Summary
    Enables RNA endonuclease activity. Involved in rRNA catabolic process and tRNA decay. Predicted to be located in cytosol; nucleoplasm; and site of DNA damage. Orthologous to several human genes including SLFN13 (schlafen family member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 1.4), thymus adult (RPKM 1.2) and 24 other tissues See more
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    Genomic context

    See Slfn8 in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82892984..82911636, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83002125..83020810, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene schlafen 9 Neighboring gene microRNA 7679 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30184 Neighboring gene schlafen 10 Neighboring gene STARR-positive B cell enhancer ABC_E10699 Neighboring gene STARR-positive B cell enhancer ABC_E8434

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC30719

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables RNA endonuclease activity PubMed 
    enables RNA endonuclease activity  
    enables tRNA binding  
    enables tRNA binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in defense response to virus  
    involved_in immune system process  
    involved_in rRNA catabolic process PubMed 
    involved_in rRNA catabolic process  
    involved_in tRNA decay PubMed 
    involved_in tRNA decay  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleus  
    located_in site of DNA damage  

    General protein information

    Preferred Names
    schlafen family member 8
    Names
    Schlafen family member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167743.1NP_001161215.1  schlafen family member 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one exon in the 5' UTR and one exon in the CDS, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL603745, BC152549
      Consensus CDS
      CCDS48869.1
      UniProtKB/TrEMBL
      A0A1G5SJK5, E9Q0R4
      Related
      ENSMUSP00000103787.3, ENSMUST00000108152.9
      Conserved Domains (2) summary
      PHA02782
      Location:45346
      PHA02782; hypothetical protein; Provisional
      pfam04326
      Location:205316
      AlbA_2; Putative DNA-binding domain
    2. NM_181545.4NP_853523.2  schlafen family member 8 isoform 1

      See identical proteins and their annotated locations for NP_853523.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL603745, AY261798
      Consensus CDS
      CCDS25155.1
      UniProtKB/Swiss-Prot
      A0A0A0MQG0, B1ARD8, F6RTS1, Q3UBN9, Q7TMF1
      UniProtKB/TrEMBL
      A0A1G5SJB6, Q7TMF0
      Related
      ENSMUSP00000040060.9, ENSMUST00000038141.15
      Conserved Domains (4) summary
      PHA02782
      Location:45346
      PHA02782; hypothetical protein; Provisional
      pfam13401
      Location:595678
      AAA_22; AAA domain
      pfam09848
      Location:595765
      DUF2075; Uncharacterized conserved protein (DUF2075)
      pfam13538
      Location:852896
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82892984..82911636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156744.1XP_036012637.1  schlafen family member 8 isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MQG0, B1ARD8, F6RTS1, Q3UBN9, Q7TMF1
      UniProtKB/TrEMBL
      A0A1G5SJB6, Q7TMF0
      Related
      ENSMUSP00000090513.5, ENSMUST00000092838.11
      Conserved Domains (4) summary
      PHA02782
      Location:45346
      PHA02782; hypothetical protein; Provisional
      pfam13401
      Location:595678
      AAA_22; AAA domain
      pfam09848
      Location:595765
      DUF2075; Uncharacterized conserved protein (DUF2075)
      pfam13538
      Location:852896
      UvrD_C_2; UvrD-like helicase C-terminal domain
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