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    ribD fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945620, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ribD
    Official Full Name
    fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
    Primary source
    ECOCYC:EG11321
    Locus tag
    b0414
    See related
    ASAP:ABE-0001441
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0408; nusII; ribG; ybaE
    Summary
    The ribD gene encodes a bifunctional enzyme that catalyzes the second (deamination) and third (reduction) steps in the riboflavin biosynthesis pathway. [More information is available at EcoCyc: EG11321].
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    Genomic context

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    Sequence:
    NC_000913.3 (433455..434558)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipoprotein YajI Neighboring gene NrdR transcriptional repressor Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase Neighboring gene transcription antitermination protein NusB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism. Stenmark P, et al. J Mol Biol, 2007 Oct 12. PMID 17765262
    2. Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin. Burrows RB, et al. J Bacteriol, 1978 Nov. PMID 30756, Free PMC Article
    3. Kinetic and mechanistic analysis of the Escherichia coli ribD-encoded bifunctional deaminase-reductase involved in riboflavin biosynthesis. Magalhães ML, et al. Biochemistry, 2008 Jun 17. PMID 18500821
    4. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. Richter G, et al. J Bacteriol, 1997 Mar. PMID 9068650, Free PMC Article
    5. Insertional disruption of the nusB (ssyB) gene leads to cold-sensitive growth of Escherichia coli and suppression of the secY24 mutation. Taura T, et al. Mol Gen Genet, 1992 Sep. PMID 1406588

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within riboflavin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
    NP_414948.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      433455..434558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414948.1 fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414948.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A485JIQ4, A0A6N0IHG2, A0A8S7E9V5
      Conserved Domains (1) summary
      PRK10786
      Location:1 → 367
      ribD; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD
    Nucleotide Protein
    Heading Accession and Version

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