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    Magea10 MAGE family member A10 [ Mus musculus (house mouse) ]

    Gene ID: 236852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Magea10provided by MGI
    Official Full Name
    MAGE family member A10provided by MGI
    Primary source
    MGI:MGI:3588211
    See related
    Ensembl:ENSMUSG00000043453 AllianceGenome:MGI:3588211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Magea10 in Genome Data Viewer
    Location:
    X A7.3; X 37.23 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71425476..71430464, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72381870..72386858, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 224 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit epsilon Neighboring gene microRNA 452 Neighboring gene STARR-seq mESC enhancer starr_47334 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 3 Neighboring gene coiled-coil domain containing 99 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47335 Neighboring gene STARR-seq mESC enhancer starr_47336 Neighboring gene microRNA 767

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Hou S, et al. Sci Rep, 2016 May 26. PMID 27226137, Free PMC Article
    2. MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Fon Tacer K, et al. Sci Adv, 2019 May. PMID 31149633, Free PMC Article
    3. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen 10
    Names
    melanoma antigen family A, 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085506.1 → NP_001078975.1  melanoma-associated antigen 10

      Status: VALIDATED

      Source sequence(s)
      AK136064
      Consensus CDS
      CCDS41002.1
      UniProtKB/TrEMBL
      A2AMW4
      Related
      ENSMUSP00000085832.5, ENSMUST00000088481.5
      Conserved Domains (2) summary
      pfam01454
      Location:138 → 293
      MAGE; MAGE family
      pfam12440
      Location:52 → 100
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      71425476..71430464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318472.1 → XP_017173961.1  melanoma-associated antigen 10 isoform X1

      UniProtKB/TrEMBL
      A2AMW4
      Conserved Domains (2) summary
      pfam01454
      Location:138 → 293
      MAGE; MAGE family
      pfam12440
      Location:52 → 100
      MAGE_N; Melanoma associated antigen family N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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