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    Filip1 filamin A interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70598, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Filip1provided by MGI
    Official Full Name
    filamin A interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1917848
    See related
    Ensembl:ENSMUSG00000034898 AllianceGenome:MGI:1917848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730485H21Rik
    Summary
    Involved in modification of postsynaptic structure. Is active in glutamatergic synapse. Is expressed in adrenal gland; bladder wall; embryo; head; and piriform cortex. Orthologous to human FILIP1 (filamin A interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 7.9), heart adult (RPKM 6.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Filip1 in Genome Data Viewer
    Location:
    9 E1; 9 43.83 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (79708461..79920135, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (79805018..80012851, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2297 Neighboring gene predicted gene, 51685 Neighboring gene RIKEN cDNA 4930429F24 gene Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene STARR-positive B cell enhancer ABC_E5090 Neighboring gene transmembrane protein 30A Neighboring gene STARR-positive B cell enhancer ABC_E11416 Neighboring gene STARR-positive B cell enhancer ABC_E2298 Neighboring gene predicted gene, 35261 Neighboring gene predicted gene, 53505 Neighboring gene STARR-seq mESC enhancer starr_24749 Neighboring gene STARR-seq mESC enhancer starr_24751 Neighboring gene STARR-seq mESC enhancer starr_24752 Neighboring gene 5'-nucleotidase domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24753 Neighboring gene STARR-seq mESC enhancer starr_24754 Neighboring gene STARR-positive B cell enhancer ABC_E715 Neighboring gene predicted gene, 46146 Neighboring gene STARR-positive B cell enhancer ABC_E8303 Neighboring gene SUMO/sentrin specific peptidase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking. Savinko T, et al. J Immunol, 2018 May 1. PMID 29581355
    2. Involvement of filamin A and filamin A-interacting protein (FILIP) in controlling the start and cell shape of radially migrating cortical neurons. Sato M, et al. Anat Sci Int, 2005 Mar. PMID 15794127
    3. A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1. Militello G, et al. J Mol Cell Biol, 2018 Apr 1. PMID 29618024, Free PMC Article
    4. Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex. Yagi H, et al. Neurosci Lett, 2016 Jan 26. PMID 26655467
    5. Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. Yagi H, et al. PLoS One, 2017. PMID 28234934, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of a novel long non-coding RNA Myolinc impairs the expression of myogenic regulatory factors and formation of multi-nucleated myotubes in cultured myoblasts. Myolinc also regulates the expression of Filip1 in a cis-manner. Similar to Myolinc, knockdown of Filip1 inhibits myogenic differentiation.
      Title: A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1.
    2. Our results reveal a role of FlnA in integrin force transmission and T cell trafficking
      Title: Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking.
    3. Hsc70 interacts with FILIP to mediate its effects on non-muscle myosin IIb and to regulate spine morphology
      Title: Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70.
    4. FILIP is a key molecule that links callosal projections to the pathogenesis of brain disorders.
      Title: Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex.
    5. Results suggest that the amount of Filamin A helps migrating neurons determine their mode of migration, multipolar or bipolar, before entering the cortical plate and that FILIP is responsible, at least in part, for Filamin A content.
      Title: Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    filamin-A-interacting protein 1
    Names
    FILIP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081243.3 → NP_001074712.1  filamin-A-interacting protein 1 isoform b

      See identical proteins and their annotated locations for NP_001074712.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC127318, AC140247
      Consensus CDS
      CCDS40704.1
      UniProtKB/Swiss-Prot
      Q059P4, Q9CS72
      Related
      ENSMUSP00000091329.5, ENSMUST00000093811.11
      Conserved Domains (3) summary
      PLN03209
      Location:955 → 1168
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      pfam09727
      Location:74 → 255
      CortBP2; Cortactin-binding protein-2
      cl25732
      Location:205 → 738
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001357352.2 → NP_001344281.1  filamin-A-interacting protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC140247, AC142111
      Conserved Domains (3) summary
      PLN03209
      Location:970 → 1183
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      pfam09727
      Location:89 → 270
      CortBP2; Cortactin-binding protein-2
      cl25732
      Location:220 → 753
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001357353.2 → NP_001344282.1  filamin-A-interacting protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC127318, AC140247
      Consensus CDS
      CCDS40704.1
      UniProtKB/Swiss-Prot
      Q059P4, Q9CS72
      Conserved Domains (3) summary
      PLN03209
      Location:955 → 1168
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      pfam09727
      Location:74 → 255
      CortBP2; Cortactin-binding protein-2
      cl25732
      Location:205 → 738
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001357354.1 → NP_001344283.1  filamin-A-interacting protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC140247, CF727145, CF738763
      Related
      ENSMUST00000172740.2
      Conserved Domains (2) summary
      PLN03209
      Location:707 → 920
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      PRK03918
      Location:3 → 498
      PRK03918; DNA double-strand break repair ATPase Rad50

    5. NM_001407987.1 → NP_001394916.1  filamin-A-interacting protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC127318, AC140247
      UniProtKB/TrEMBL
      A0A5F8MPD6
      Related
      ENSMUSP00000158921.2, ENSMUST00000239133.2

    6. NM_001407988.1 → NP_001394917.1  filamin-A-interacting protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC140247

    7. NM_001407989.1 → NP_001394918.1  filamin-A-interacting protein 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC140247

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      79708461..79920135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CS72.3 GenPept UniProtKB/Swiss-Prot:Q9CS72

    Gene LinkOut

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