Zw10 zw10 kinetochore protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zw10provided by MGI
Official Full Name: zw10 kinetochore proteinprovided by MGI
Primary source: MGI:MGI:1349478
See related: Ensembl:ENSMUSG00000032264 AllianceGenome:MGI:1349478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MmZw10; 6330566F14Rik
Summary: Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and regulation of mitotic cell cycle phase transition. Predicted to be located in several cellular components, including kinetochore; lipid droplet; and spindle. Predicted to be part of Dsl1/NZR complex and RZZ complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 15.1), limb E14.5 (RPKM 13.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.58 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (48966880..48990075)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (49055576..49078775)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results demonstrate that Zw10 is localized at kinetochores and functions as an essential spindle assembly checkpoint component in mouse oocytes
Title: Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Dsl1/NZR complex	IEA Inferred from Electronic Annotation more info
part_of Dsl1/NZR complex	ISO Inferred from Sequence Orthology more info
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RZZ complex	IEA Inferred from Electronic Annotation more info
part_of RZZ complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centromere/kinetochore protein zw10 homolog

Names: ZW10 homolog, centromere/kinetochore protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012039.2 → NP_036169.1 centromere/kinetochore protein zw10 homolog

See identical proteins and their annotated locations for NP_036169.1

Status: VALIDATED

Source sequence(s)

AK168479, BC067405, CJ172982

Consensus CDS

CCDS23161.1

UniProtKB/Swiss-Prot

O54692, Q3TIA5, Q3ULW1, Q921H3

Related

ENSMUSP00000034803.9, ENSMUST00000034803.10

Conserved Domains (2) summary

pfam06248
Location:9 → 621

Zw10; Centromere/kinetochore Zw10

cl21453
Location:598 → 768

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

48966880..48990075

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510371.4 → XP_006510434.1 centromere/kinetochore protein zw10 homolog isoform X1

Conserved Domains (2) summary

pfam06248
Location:5 → 347

Zw10; Centromere/kinetochore Zw10

cl21453
Location:381 → 551

PKc_like; Protein Kinases, catalytic domain