Spata4 spermatogenesis associated 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata4provided by MGI
Official Full Name: spermatogenesis associated 4provided by MGI
Primary source: MGI:MGI:1916531
See related: Ensembl:ENSMUSG00000031518 AllianceGenome:MGI:1916531
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srg2; TSARG2; 1700001N01Rik
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in regulation of cytoskeleton organization. Located in cytoplasm. Orthologous to human SPATA4 (spermatogenesis associated 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 240.1) See more
Orthologs: human all
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Genomic context

Location:: 8 B1.3; 8 29.27 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (55053816..55063133)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (54600781..54610098)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter.
Title: Spermatogenesis associated 4 promotes Sertoli cell proliferation modulated negatively by regulatory factor X1.
Spata4 promotes osteoblast differentiation and mineralization through the Erk-activated Runx2 pathway.
Title: Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway.
analysis of SPATA4 expression and variation in promotor sequences
Title: Molecular cloning and bioinformatic analysis of SPATA4 gene.
RT-PCR showed that SRG2 was expressed significantly in testis.
Title: [Molecular cloning of SRG2, a mouse testis spermatocyte apoptosis-related gene].
Srg2 gene was found up-regulated distinctly and playing an important role in cryptorchid testis.
Title: [Molecular cloning and expression in cryptorchid testis of SRG2 from a mouse testis spermatocyte apoptosis-related gene].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spermatogenesis-associated protein 4

Names: spermatogenesis-related gene 2 protein; testis and spermatogenesis cell-related protein 2; testis spermatocyte apoptosis-related gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.