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    Asb5 ankyrin repeat and SOCs box-containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 76294, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Asb5provided by MGI
    Official Full Name
    ankyrin repeat and SOCs box-containing 5provided by MGI
    Primary source
    MGI:MGI:1923544
    See related
    Ensembl:ENSMUSG00000031519 AllianceGenome:MGI:1923544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110018D09Rik
    Summary
    Predicted to be involved in positive regulation of protein catabolic process and protein ubiquitination. Is expressed in central nervous system and retina. Orthologous to human ASB5 (ankyrin repeat and SOCS box containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 10.1), heart adult (RPKM 9.8) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb5 in Genome Data Viewer
    Location:
    8 B1.3; 8 29.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (55003366..55040877)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (54550331..54587842)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33153 Neighboring gene vascular endothelial growth factor C Neighboring gene STARR-seq mESC enhancer starr_21496 Neighboring gene STARR-positive B cell enhancer ABC_E5005 Neighboring gene RIKEN cDNA 5330439A09 gene Neighboring gene signal peptidase complex subunit 3 homolog (S. cerevisiae) Neighboring gene predicted gene, 46039 Neighboring gene spermatogenesis associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118455

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 5
    Names
    ASB-5
    ankyrin repeat and SOCs box-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374794.1 → NP_001361723.1  ankyrin repeat and SOCS box protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102933
      Consensus CDS
      CCDS90397.1
      UniProtKB/TrEMBL
      A0A5F8MPR8
      Related
      ENSMUSP00000159077.2, ENSMUST00000239166.2
      Conserved Domains (3) summary
      cd03724
      Location:264 → 305
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:47 → 76
      ANK; ANK repeat [structural motif]
      cl39094
      Location:49 → 265
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001374795.1 → NP_001361724.1  ankyrin repeat and SOCS box protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102933
      Consensus CDS
      CCDS90398.1
      UniProtKB/TrEMBL
      A0A5F8MPD7
      Related
      ENSMUSP00000158922.2, ENSMUST00000239106.2
      Conserved Domains (3) summary
      cd03724
      Location:243 → 284
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:26 → 55
      ANK; ANK repeat [structural motif]
      cl39094
      Location:17 → 244
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_029569.3 → NP_083845.1  ankyrin repeat and SOCS box protein 5 isoform 1

      See identical proteins and their annotated locations for NP_083845.1

      Status: VALIDATED

      Source sequence(s)
      AC102933
      Consensus CDS
      CCDS22307.1
      UniProtKB/Swiss-Prot
      Q9D1A4
      UniProtKB/TrEMBL
      Q2VPQ8
      Related
      ENSMUSP00000033918.3, ENSMUST00000033918.4
      Conserved Domains (3) summary
      cd03724
      Location:288 → 329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]
      cl39094
      Location:73 → 289
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      55003366..55040877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509520.5 → XP_006509583.1  ankyrin repeat and SOCS box protein 5 isoform X1

      Conserved Domains (3) summary
      cd03724
      Location:235 → 276
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:18 → 47
      ANK; ANK repeat [structural motif]
      cl39094
      Location:2 → 236
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1A4.1 GenPept UniProtKB/Swiss-Prot:Q9D1A4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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