Spag11a sperm associated antigen 11A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spag11aprovided by MGI
Official Full Name: sperm associated antigen 11Aprovided by MGI
Primary source: MGI:MGI:1925378
See related: Ensembl:ENSMUSG00000079842 AllianceGenome:MGI:1925378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP2Q; EP2e; Bin1b; Spag11; 9230111C08Rik
Summary: Acts upstream of or within antimicrobial humoral response and negative regulation of interleukin-1 production. Located in cell surface and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 82.1) See more
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Genomic context

Location:: 8 A1.3; 8 10.35 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (19207229..19209936)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (19157213..19159920)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Spag11a has a specific role in epididymal sperm maturation.
Title: Sperm-associated antigen 11A is expressed exclusively in the principal cells of the mouse caput epididymis in an androgen-dependent manner.
Model was developed in which Bin1b was exclusively overexpressed by up to 50-fold in the caput epididymis. The transgenic mice are healthy with normal reproductive activity, but are more resistant to epididymal infection from E coli than normal animals.
Title: mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge.
increased expression in response to lipopolysaccharide administration
Title: Antimicrobial responses in the male reproductive tract of lipopolysaccharide challenged rats.
The epididymis-specific expression pattern of the beta-defensin isoform EP2e has been characterized.
Title: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495676

NoName (e-PCR)
- UniSTS:493004

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antifungal humoral response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antifungal humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-1 alpha production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sperm-associated antigen 11A

Names: EP2 protein; antimicrobial peptide Bin1b; antimicrobial-like protein Bin-1b; beta defensin EP2e; sperm-associated antigen 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.