Calca calcitonin/calcitonin-related polypeptide, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calcaprovided by MGI
Official Full Name: calcitonin/calcitonin-related polypeptide, alphaprovided by MGI
Primary source: MGI:MGI:2151253
See related: Ensembl:ENSMUSG00000030669 AllianceGenome:MGI:2151253
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1
Summary: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]
Expression: Biased expression in CNS E11.5 (RPKM 1.9), cerebellum adult (RPKM 1.7) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 59.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (114225223..114236145, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (114625981..114636910, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice.
Title: Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice.
A Vestibular Challenge Combined with Calcitonin Gene-Related Peptide (CGRP) Promotes Anxiety-Like Behaviors.
Title: A Vestibular Challenge Combined with Calcitonin Gene-Related Peptide (CGRP) Promotes Anxiety-Like Behaviors.
Activation of CGRP receptor-mediated signaling promotes tendon-bone healing.
Title: Activation of CGRP receptor-mediated signaling promotes tendon-bone healing.
Loss of calcitonin gene-related peptide (alphaCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice.
Title: Loss of calcitonin gene-related peptide (αCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice.
Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice.
Title: Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice.
Sensory nerves, but not sympathetic nerves, promote reparative dentine formation after dentine injury via CGRP-mediated angiogenesis: An in vivo study.
Title: Sensory nerves, but not sympathetic nerves, promote reparative dentine formation after dentine injury via CGRP-mediated angiogenesis: An in vivo study.
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Title: Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin.
Title: Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin.
Calcitonin gene-related peptide: An intra-articular therapeutic target for TMJ disorders.
Title: Calcitonin gene-related peptide: An intra-articular therapeutic target for TMJ disorders.
[Calcitonin gene-related peptides protect against oxidative stress-induced lung injury via increasing autophagy in neonatal rats].
Title: [Calcitonin gene-related peptides protect against oxidative stress-induced lung injury via increasing autophagy in neonatal rats].

Submit: New GeneRIF Correction See all GeneRIFs (168)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (11) 1 citation

General gene information

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Markers

PMC151647P1 (e-PCR)
- UniSTS:271162

PMC109322P1 (e-PCR)
- UniSTS:270162

X97991 (e-PCR)
- UniSTS:163425

Calca (e-PCR), detects polymorphism
- UniSTS:141215

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcitonin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcitonin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables calcitonin receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within activation of adenylate cyclase activity	ISA Inferred from Sequence Alignment more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell adhesion	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within feeding behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of blood pressure	ISA Inferred from Sequence Alignment more info	PubMed
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell adhesion	IDA Inferred from Direct Assay more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sperm capacitation	ISA Inferred from Sequence Alignment more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcitonin gene-related peptide 1

Names: alpha-type CGRP; calcitonin gene-related peptide I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033954.3 → NP_001029126.1 calcitonin gene-related peptide 1 isoform Cgrp preproprotein

See identical proteins and their annotated locations for NP_001029126.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks the 3' terminal exon and has two alternate 3' exons, compared to variant 1. The resulting isoform (Cgrp) is shorter and has a distinct C-terminus, compared to isoform Calca. Both variants 2 and 3 encode the same isoform Cgrp.

Source sequence(s)

BB749493, BC028771, BU842988, CJ060164

Consensus CDS

CCDS21762.1

UniProtKB/Swiss-Prot

Q99JA0

Related

ENSMUSP00000032906.5, ENSMUST00000032906.11

Conserved Domains (1) summary

pfam00214
Location:1 → 124

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
NM_001289444.1 → NP_001276373.1 calcitonin gene-related peptide 1 isoform Cgrp preproprotein

See identical proteins and their annotated locations for NP_001276373.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an altenate splice site in the 5' UTR, lacks the 3' terminal exon and has two alternate 3' exons, compared to variant 1. The resulting isoform (Cgrp) is shorter and has a distinct C-terminus, compared to isoform Calca. Both variants 2 and 3 encode the same isoform Cgrp.

Source sequence(s)

AF330212, BB749493, BC028771, BU842988, CJ057527, CJ060164

Consensus CDS

CCDS21762.1

UniProtKB/Swiss-Prot

Q99JA0

Conserved Domains (1) summary

pfam00214
Location:1 → 124

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
NM_001305616.1 → NP_001292545.1 calcitonin gene-related peptide 1 isoform Calca preproprotein

See identical proteins and their annotated locations for NP_001292545.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform Calca.

Source sequence(s)

AC156617, AK132582, BC030071, CJ060164

Consensus CDS

CCDS21763.1

UniProtKB/Swiss-Prot

P70160, Q8K1K5

UniProtKB/TrEMBL

Q3V1A7

Related

ENSMUSP00000146328.2, ENSMUST00000206853.2

Conserved Domains (1) summary

pfam00214
Location:1 → 121

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
NM_007587.2 → NP_031613.2 calcitonin gene-related peptide 1 isoform Calca preproprotein

See identical proteins and their annotated locations for NP_031613.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (Calca). Both variants 1 and 4 encode the same protein.

Source sequence(s)

BC030071, CJ060164, X97991

Consensus CDS

CCDS21763.1

UniProtKB/Swiss-Prot

P70160, Q8K1K5

UniProtKB/TrEMBL

Q3V1A7

Related

ENSMUSP00000032907.8, ENSMUST00000032907.9

Conserved Domains (1) summary

pfam00214
Location:1 → 121

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

114225223..114236145 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241660.4 → XP_011239962.1 calcitonin gene-related peptide 1 isoform X2

See identical proteins and their annotated locations for XP_011239962.1

UniProtKB/Swiss-Prot

Q99JA0

Conserved Domains (1) summary

pfam00214
Location:1 → 124

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
XM_030242032.1 → XP_030097892.1 calcitonin gene-related peptide 1 isoform X2

UniProtKB/Swiss-Prot

Q99JA0

Conserved Domains (1) summary

pfam00214
Location:1 → 124

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
XM_030242031.1 → XP_030097891.1 calcitonin gene-related peptide 1 isoform X1

UniProtKB/Swiss-Prot

P70160, Q8K1K5

UniProtKB/TrEMBL

Q3V1A7

Conserved Domains (1) summary

pfam00214
Location:1 → 121

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family