Spon1 spondin 1, (f-spondin) extracellular matrix protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spon1provided by MGI
Official Full Name: spondin 1, (f-spondin) extracellular matrix proteinprovided by MGI
Primary source: MGI:MGI:2385287
See related: Ensembl:ENSMUSG00000038156 AllianceGenome:MGI:2385287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FSP; D330035F22Rik
Summary: Enables LBD domain binding activity. Acts upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix. Is expressed in several structures, including aorta; craniocervical region bone; nervous system; palatal shelf; and sensory organ. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 35.4), ovary adult (RPKM 16.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 59.25 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (113365235..113642610)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (113765998..114043375)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.
Title: SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.
We conclude that 2ME impairs mouse embryo implantation via activation of F-spondin in the uterus.
Title: 2-Methoxyoestradiol impairs mouse embryo implantation via F-spondin.
Study identified a novel role for the extracellular matrix protein F-spondin in circadian behavior. In the absence of F-spondin, mice lost their ability to maintain typical intrinsic rhythmicity. Moreover, F-spondin loss results in the displacement of vasoactive intestinal peptide (VIP)-expressing neurons, a class of neurons that are essential for maintaining rhythmicity among suprachiasmatic nucleus neurons.
Title: F-spondin Is Essential for Maintaining Circadian Rhythms.
We conclude that upon ligand binding, TLR4 activates PI3K/Akt signaling to induce F-spondin expression, subsequently control CREB-mediated IL-6 production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis.
Title: TLR4 induces CREB-mediated IL-6 production via upregulation of F-spondin to promote vascular smooth muscle cell migration.
These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages.
Title: Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent.
Spon1 deletion leads to a local and systemic reduction of TGF-beta levels resulting in increased BMP signaling and increased bone deposition in adult mice.
Title: F-spondin deficient mice have a high bone mass phenotype.
F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization.
Title: F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

18.MMHAP84FRF9.seq (e-PCR)
- UniSTS:123402

Spon1 (e-PCR), detects polymorphism
- UniSTS:526944

AW455831 (e-PCR)
- UniSTS:179627

AI666765 (e-PCR)
- UniSTS:165550

Spon1 (e-PCR), detects polymorphism
- UniSTS:532688

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables LBD domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of amyloid precursor protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spondin-1

Names: F-spondin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145584.2 → NP_663559.1 spondin-1 precursor

See identical proteins and their annotated locations for NP_663559.1

Status: VALIDATED

Source sequence(s)

AC102861, AC118201, AC158213

Consensus CDS

CCDS21757.1

UniProtKB/Swiss-Prot

Q8K2Q8, Q8VCC9

UniProtKB/TrEMBL

Q69ZZ7

Related

ENSMUSP00000041157.10, ENSMUST00000046687.16

Conserved Domains (3) summary

cd08544
Location:43 → 182

Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam00090
Location:562 → 610

TSP_1; Thrombospondin type 1 domain

pfam06468
Location:205 → 392

Spond_N; Spondin_N