Rbm46 RNA binding motif protein 46 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm46provided by MGI
Official Full Name: RNA binding motif protein 46provided by MGI
Primary source: MGI:MGI:3645057
See related: Ensembl:ENSMUSG00000033882 AllianceGenome:MGI:3645057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm761; EG633285
Summary: Enables RNA binding activity. Involved in several processes, including cell cycle switching, mitotic to meiotic cell cycle; meiotic nuclear division; and spermatid differentiation. Acts upstream of or within mRNA stabilization and trophectodermal cell differentiation. Located in cytoplasm and nucleus. Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; lung; and rib. Orthologous to human RBM46 (RNA binding motif protein 46). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 4.6), placenta adult (RPKM 1.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 36.75 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (82743828..82783828, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (82836521..82876512, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy.
Title: Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy.
RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.
Title: RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.
The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice.
Title: The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice.
RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.
Title: RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.
Rbm46 directly binds to and stabilizes Cdx2 mRNA in early mouse embryos.
Title: Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

General gene information

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Markers

EG633285 (e-PCR), detects polymorphism
- UniSTS:479115

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: probable RNA-binding protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146328.3 → NP_001139800.1 probable RNA-binding protein 46 isoform 1

Status: VALIDATED

Source sequence(s)

AC102130, AC158935

Consensus CDS

CCDS50938.1

UniProtKB/Swiss-Prot

P86049

UniProtKB/TrEMBL

S4R2P5

Related

ENSMUSP00000045511.7, ENSMUST00000048647.14

Conserved Domains (1) summary

TIGR01648
Location:5 → 464

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
NM_001277170.1 → NP_001264099.1 probable RNA-binding protein 46 isoform 2

Status: VALIDATED

Source sequence(s)

AC102130, AC158935, AV254043, CJ047211

Consensus CDS

CCDS71255.1

UniProtKB/TrEMBL

S4R1Y9, S4R2P5

Related

ENSMUSP00000138429.2, ENSMUST00000182818.3

Conserved Domains (1) summary

TIGR01648
Location:5 → 464

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
NM_001415722.1 → NP_001402651.1 probable RNA-binding protein 46 isoform 2

Status: VALIDATED

Source sequence(s)

AC102130, AC158935

UniProtKB/TrEMBL

S4R1Y9
NM_001415724.1 → NP_001402653.1 probable RNA-binding protein 46 isoform 2

Status: VALIDATED

Source sequence(s)

AC102130, AC158935

UniProtKB/TrEMBL

S4R1Y9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

82743828..82783828 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501850.4 → XP_006501913.1 probable RNA-binding protein 46 isoform X1

See identical proteins and their annotated locations for XP_006501913.1

UniProtKB/Swiss-Prot

P86049

UniProtKB/TrEMBL

S4R2P5

Conserved Domains (1) summary

TIGR01648
Location:5 → 464

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
XM_006501851.3 → XP_006501914.1 probable RNA-binding protein 46 isoform X1

See identical proteins and their annotated locations for XP_006501914.1

UniProtKB/Swiss-Prot

P86049

UniProtKB/TrEMBL

S4R2P5

Conserved Domains (1) summary

TIGR01648
Location:5 → 464

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
XM_011240188.3 → XP_011238490.1 probable RNA-binding protein 46 isoform X1

See identical proteins and their annotated locations for XP_011238490.1

UniProtKB/Swiss-Prot

P86049

UniProtKB/TrEMBL

S4R2P5

Conserved Domains (1) summary

TIGR01648
Location:5 → 464

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family