Qrfpr pyroglutamylated RFamide peptide receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Qrfprprovided by MGI
Official Full Name: pyroglutamylated RFamide peptide receptorprovided by MGI
Primary source: MGI:MGI:2677633
See related: Ensembl:ENSMUSG00000058400 AllianceGenome:MGI:2677633
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AQ27; Gpr103; SP9155; Gpr103a
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Located in non-motile cilium. Is expressed in ventral pallium. Used to study bone structure disease. Orthologous to human QRFPR (pyroglutamylated RFamide peptide receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 1.2), frontal lobe adult (RPKM 0.8) and 8 other tissues See more
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Genomic context

Location:: 3 B; 3 17.41 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (36233575..36276462, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (36179426..36222275, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
Title: The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development
Title: Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development.
we treated mice with the synthetic GPR103 receptor agonist peptide P550 and the anxious behavior was investigated using an elevated plus-maze test.
Title: Anxiolytic effect of the GPR103 receptor agonist peptide P550 (homolog of neuropeptide 26RFa) in mice. Involvement of neurotransmitters.
Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
Title: GPR103b functions in the peripheral regulation of adipogenesis.
Osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone.
Title: The G-protein-coupled receptor GPR103 regulates bone formation.
QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
characterization and tissue distribution of SP9155 (GPR103) ligand [GPR103/SP9155]
Title: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyroglutamylated RF-amide peptide receptor

Names: G protein-coupled receptor 103; QRFP receptor; orexigenic neuropeptide QRFP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198192.3 → NP_937835.1 pyroglutamylated RF-amide peptide receptor

See identical proteins and their annotated locations for NP_937835.1

Status: VALIDATED

Source sequence(s)

AC102844

Consensus CDS

CCDS17311.1

UniProtKB/Swiss-Prot

P83861

UniProtKB/TrEMBL

Q3UQ27, Q4VA00

Related

ENSMUSP00000088768.6, ENSMUST00000091227.9

Conserved Domains (1) summary

cd15205
Location:46 → 343

7tmA_QRFPR; pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors