U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Npepl1 aminopeptidase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 228961, updated on 27-Nov-2024

    Summary

    Official Symbol
    Npepl1provided by MGI
    Official Full Name
    aminopeptidase-like 1provided by MGI
    Primary source
    MGI:MGI:2448523
    See related
    Ensembl:ENSMUSG00000039263 AllianceGenome:MGI:2448523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1974
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human NPEPL1 (aminopeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 80.4), adrenal adult (RPKM 69.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Npepl1 in Genome Data Viewer
    Location:
    2 H4; 2 97.87 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173951904..173964495)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174110338..174122702)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7892 Neighboring gene syntaxin 16 Neighboring gene predicted gene 10714 Neighboring gene STARR-seq mESC enhancer starr_06632 Neighboring gene microRNA 296

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable aminopeptidase NPEPL1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378793.1NP_001365722.1  probable aminopeptidase NPEPL1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669896
      UniProtKB/TrEMBL
      Q3TCV9, Q3U199, Q3UD03
      Conserved Domains (1) summary
      cd00433
      Location:35492
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    2. NM_213733.2NP_998898.1  probable aminopeptidase NPEPL1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK150313, BU148687, BX517579
      Consensus CDS
      CCDS17148.1
      UniProtKB/Swiss-Prot
      A2ACM6, Q66JY0, Q6NSR8
      UniProtKB/TrEMBL
      Q3TCV9, Q3U199, Q3UD03
      Related
      ENSMUSP00000042808.10, ENSMUST00000044415.16
      Conserved Domains (1) summary
      cd00433
      Location:35487
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173951904..173964495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_374463.2 RNA Sequence

    2. XR_374462.2 RNA Sequence