Ppp1r3c protein phosphatase 1, regulatory subunit 3C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r3cprovided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 3Cprovided by MGI
Primary source: MGI:MGI:1858229
See related: Ensembl:ENSMUSG00000067279 AllianceGenome:MGI:1858229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTG; Ppp1r5
Summary: Enables glycogen binding activity; molecular adaptor activity; and protein phosphatase binding activity. Involved in glycogen biosynthetic process. Acts upstream of or within glycogen metabolic process. Is active in cytosol. Is expressed in genitourinary system; liver; and nasal capsule. Used to study type 2 diabetes mellitus. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in heart adult (RPKM 24.0), liver E18 (RPKM 21.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 31.89 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (36709131..36714004, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (36731731..36736604, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased liver glycogen levels enhance exercise capacity in mice.
Title: Increased liver glycogen levels enhance exercise capacity in mice.
GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease.
Title: GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease.
Metformin-activated AMPK decreases hepatic PPP1R3C expression, leading to the suppression of hepatic gluconeogenesis through blocking cAMP-stimulated TORC2 dephosphorylation
Title: PPP1R3C mediates metformin-inhibited hepatic gluconeogenesis.
metabolic crosstalk is due to decreased mTORC1 and SREBP activity in PTG knockout mice or knockdown cells, suggesting a positive feedback loop in which once accumulated, glycogen stimulates the mTORC1/SREBP1 pathway to shift energy storage to lipogenesis.
Title: Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity.
removing PTG, a glycogen synthesis activator protein, nearly completely eliminates Lafora bodies and rescues the neurodegeneration, myoclonus,seizure susceptibility, and behavioral abnormality.
Title: PTG protein depletion rescues malin-deficient Lafora disease in mouse.
Laforin-deficient mice lacking PTG have greatly decreased Lafora bodies and normal glycogen levels.
Title: PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease.
PTG overexpression in 3T3-L1 adipocytes discretely stimulates PP1 activity against glycogen synthase and phosphorylase, resulting in a marked and specific increase in glucose uptake and storage as glycogen.
Title: Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytes.
mouse protein targeting to glycogen (PTG) promoter is regulated by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells
Title: Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells.
These data indicate that disruption of PTG expression resulted in the uncoupling of PP1 activity from glycogen metabolizing enzymes, the enhancement of glycogenolysis, and a dramatic decrease in cellular glycogen levels.
Title: Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes.
These data suggest that PTG plays a critical role in glycogen synthesis and is necessary to maintain the appropriate metabolic balance for the partitioning of fuel substrates between glycogen and lipid.
Title: PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables [phosphorylase] phosphatase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glycogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen binding	IEP Inferred from Expression Pattern more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein targeting	TAS Traceable Author Statement more info	PubMed
involved_in regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in glycogen granule	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 3C

Names: PP1 subunit R5; protein phosphatase 1 binding protein PTG; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein phosphatase 1, regulatory (inhibitor) subunit 5; protein targeting to glicogen; protein targeting to glycogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.