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    Flywch1 FLYWCH-type zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 224613, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Flywch1provided by MGI
    Official Full Name
    FLYWCH-type zinc finger 1provided by MGI
    Primary source
    MGI:MGI:2442638
    See related
    Ensembl:ENSMUSG00000040097 AllianceGenome:MGI:2442638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1552; E030034P13Rik
    Summary
    Predicted to enable transcription coactivator binding activity and transcription corepressor activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear body; and pericentric heterochromatin. Predicted to be part of transcription regulator complex. Is expressed in several structures, including adrenal gland; aorta; genitourinary system; nervous system; and neural retina. Orthologous to human FLYWCH1 (FLYWCH-type zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 34.9), testis adult (RPKM 26.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Flywch1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.04 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23971767..23993504, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23752795..23774530, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene progestin and adipoQ receptor family member IV Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene kringle containing transmembrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4197 Neighboring gene FLYWCH family member 2 Neighboring gene predicted gene, 52285 Neighboring gene serine/arginine repetitive matrix 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription coactivator binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentric heterochromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FLYWCH-type zinc finger-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357993.1 → NP_001344922.1  FLYWCH-type zinc finger-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122821, AI849618
      UniProtKB/TrEMBL
      A0A2I3BRL2
      Conserved Domains (3) summary
      pfam04500
      Location:235 → 293
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:294 → 351
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    2. NM_001357994.1 → NP_001344923.1  FLYWCH-type zinc finger-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122821, AI849618
      UniProtKB/TrEMBL
      A0A2I3BRL2
      Related
      ENSMUSP00000154618.2, ENSMUST00000227120.2
      Conserved Domains (3) summary
      pfam04500
      Location:235 → 293
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:294 → 351
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    3. NM_153791.2 → NP_722486.2  FLYWCH-type zinc finger-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_722486.2

      Status: VALIDATED

      Source sequence(s)
      AK168389, BY128897, CA321280, CD553578
      Consensus CDS
      CCDS28463.1
      UniProtKB/Swiss-Prot
      E9QKQ2, Q3TH83, Q6ZPN0, Q8C792, Q8CI03
      UniProtKB/TrEMBL
      A0A2I3BRL2
      Related
      ENSMUSP00000083505.6, ENSMUST00000086325.13
      Conserved Domains (3) summary
      pfam04500
      Location:235 → 293
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:294 → 401
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23971767..23993504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524082.5 → XP_006524145.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006524145.1

      UniProtKB/TrEMBL
      A0A2I3BRL2
      Conserved Domains (3) summary
      pfam04500
      Location:235 → 293
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:294 → 351
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    2. XM_006524083.5 → XP_006524146.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006524146.1

      UniProtKB/TrEMBL
      A0A2I3BRL2
      Conserved Domains (3) summary
      pfam04500
      Location:235 → 293
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:294 → 351
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI03.2 GenPept UniProtKB/Swiss-Prot:Q8CI03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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