Trem6l triggering receptor expressed on myeloid cells-like 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trem6lprovided by MGI
Official Full Name: triggering receptor expressed on myeloid cells-like 6provided by MGI
Primary source: MGI:MGI:2443478
See related: Ensembl:ENSMUSG00000043740 AllianceGenome:MGI:2443478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Treml6; B430306N03Rik
Summary: Predicted to enable signaling receptor activity. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 4.5), testis adult (RPKM 4.0) and 13 other tissues See more
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Genomic context

Location:: 17 C; 17 23.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48622310..48632580)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48315279..48326511)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that that a set of Trem receptors are up-regulated in response to viral RNA to regulate myeloid cell activation through modulation of DAP12-associated Trem4 and ITIM-containing Treml6
Title: Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trem-like transcript 6 protein

Names: triggering receptor expressed on myeloid cells-like 6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418741.1 → NP_001405670.1 trem-like transcript 6 protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC166164
NM_177083.5 → NP_796057.1 trem-like transcript 6 protein isoform 1 precursor

See identical proteins and their annotated locations for NP_796057.1

Status: VALIDATED

Source sequence(s)

AC166164

Consensus CDS

CCDS28864.1

UniProtKB/TrEMBL

Q6QX36

Related

ENSMUSP00000054890.7, ENSMUST00000049614.13

Conserved Domains (2) summary

cd05716
Location:28 → 121

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:26 → 121

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48622310..48632580

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524395.5 → XP_006524458.1 trem-like transcript 6 protein isoform X2

Conserved Domains (1) summary

cd05716
Location:28 → 121

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
XM_006524394.5 → XP_006524457.1 trem-like transcript 6 protein isoform X1

Conserved Domains (1) summary

cd05716
Location:28 → 121

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains