Atpsckmt ATP synthase C subunit lysine N-methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atpsckmtprovided by MGI
Official Full Name: ATP synthase C subunit lysine N-methyltransferaseprovided by MGI
Primary source: MGI:MGI:1915323
See related: Ensembl:ENSMUSG00000039065 AllianceGenome:MGI:1915323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam173b; mFam173b; A930016P21Rik
Summary: Enables protein-lysine N-methyltransferase activity. Involved in several processes, including peptidyl-lysine trimethylation; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; and positive regulation of sensory perception of pain. Predicted to be located in mitochondrial crista. Predicted to be active in mitochondrion. Is expressed in embryo. Orthologous to human ATPSCKMT (ATP synthase c subunit lysine N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 6.0), CNS E11.5 (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B2; 15 13.02 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (31602262..31624652)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (31602116..31617537)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we uncover a role for methyltransferase activity of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase activity as a potential therapeutic target to treat debilitating chronic pain conditions
Title: Identification of FAM173B as a protein methyltransferase promoting chronic pain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine trimethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine trimethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial ATP synthesis coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial ATP synthesis coupled proton transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial ATP synthesis coupled proton transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in mitochondrial crista	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP synthase subunit C lysine N-methyltransferase

Names: family with sequence similarity 173, member B; protein FAM173B; protein N-lysine methyltransferase FAM173B

NP_001343242.1

EC 2.1.1.-

NP_080822.1

EC 2.1.1.-

XP_030104583.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356313.1 → NP_001343242.1 ATP synthase subunit C lysine N-methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

AC137842

Consensus CDS

CCDS88746.1

UniProtKB/TrEMBL

E0CXY7

Related

ENSMUSP00000124619.3, ENSMUST00000161061.3

Conserved Domains (1) summary

TIGR02021
Location:9 → 79

BchM-ChlM; magnesium protoporphyrin O-methyltransferase
NM_026546.3 → NP_080822.1 ATP synthase subunit C lysine N-methyltransferase isoform 1

See identical proteins and their annotated locations for NP_080822.1

Status: VALIDATED

Source sequence(s)

AC137842

Consensus CDS

CCDS27412.1

UniProtKB/Swiss-Prot

Q8K2S1, Q9D1Z3

Related

ENSMUSP00000039094.7, ENSMUST00000042702.7

Conserved Domains (1) summary

TIGR02021
Location:87 → 157

BchM-ChlM; magnesium protoporphyrin O-methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

31602262..31624652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248723.2 → XP_030104583.1 ATP synthase subunit C lysine N-methyltransferase isoform X1

UniProtKB/TrEMBL

E0CXY7

Conserved Domains (1) summary

TIGR02021
Location:9 → 79

BchM-ChlM; magnesium protoporphyrin O-methyltransferase