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    Synpr synaptoporin [ Mus musculus (house mouse) ]

    Gene ID: 72003, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Synprprovided by MGI
    Official Full Name
    synaptoporinprovided by MGI
    Primary source
    MGI:MGI:1919253
    See related
    Ensembl:ENSMUSG00000056296 AllianceGenome:MGI:1919253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPO; 1500003F20Rik
    Summary
    Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be located in neuron projection. Predicted to be active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Is expressed in central nervous system; dorsal root ganglion; and thymus primordium. Orthologous to human SYNPR (synaptoporin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 55.9), cortex adult (RPKM 12.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Synpr in Genome Data Viewer
    Location:
    14 A1; 14 6.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (8854294..9184983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (13284780..13615469)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_35973 Neighboring gene sentan, cilia apical structure protein Neighboring gene STARR-seq mESC enhancer starr_35970 Neighboring gene STARR-seq mESC enhancer starr_35969 Neighboring gene predicted gene 5087 Neighboring gene STARR-seq mESC enhancer starr_35968 Neighboring gene STARR-seq mESC enhancer starr_35966 Neighboring gene STARR-seq mESC enhancer starr_35965 Neighboring gene STARR-seq mESC enhancer starr_35964 Neighboring gene STARR-seq mESC enhancer starr_35963 Neighboring gene STARR-seq mESC enhancer starr_35962 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn. Chung J, et al. Sci Rep, 2019 Mar 12. PMID 30862809, Free PMC Article
    2. Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons. Singec I, et al. J Comp Neurol, 2002 Oct 14. PMID 12271488
    3. Structural abnormalities in the primary somatosensory cortex and a normal behavioral profile in Contactin-5 deficient mice. Kleijer KTE, et al. Cell Adh Migr, 2018 Jan 2. PMID 28346043, Free PMC Article
    4. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Raja MK, et al. Elife, 2019 May 15. PMID 31090538, Free PMC Article
    5. New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation. Mata A, et al. Sci Rep, 2018 Jan 22. PMID 29358640, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
      Title: Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptoporin
    Names
    synaptorin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163032.1 → NP_001156504.1  synaptoporin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156504.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC132330, AK032442, AK049661, CD354682
      Consensus CDS
      CCDS49402.1
      UniProtKB/Swiss-Prot
      Q8BGN8, Q8C5J4, Q9DB89
      Related
      ENSMUSP00000108275.3, ENSMUST00000112656.4
      Conserved Domains (1) summary
      pfam01284
      Location:69 → 196
      MARVEL; Membrane-associating domain

    2. NM_028052.4 → NP_082328.3  synaptoporin isoform 1

      See identical proteins and their annotated locations for NP_082328.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132330, AK005132, AK049661, AK078223
      Consensus CDS
      CCDS26821.1
      UniProtKB/Swiss-Prot
      Q8BGN8
      Related
      ENSMUSP00000064986.6, ENSMUST00000070323.12
      Conserved Domains (1) summary
      pfam01284
      Location:15 → 216
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      8854294..9184983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGN8.1 GenPept UniProtKB/Swiss-Prot:Q8BGN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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