Taar5 trace amine-associated receptor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taar5provided by MGI
Official Full Name: trace amine-associated receptor 5provided by MGI
Primary source: MGI:MGI:2685073
See related: Ensembl:ENSMUSG00000069706 AllianceGenome:MGI:2685073
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm227; taR-5
Summary: Enables trimethylamine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cognition; and sensory perception of chemical stimulus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in Grueneberg ganglion; endolymphatic duct; nasal septum; olfactory epithelium; and utricle. Orthologous to human TAAR5 (trace amine associated receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.4 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23846604..23847617)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23970706..23971719)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice.
Title: Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice.
Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions.
Title: Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions.
Increased dopamine transmission and adult neurogenesis in trace amine-associated receptor 5 (TAAR5) knockout mice.
Title: Increased dopamine transmission and adult neurogenesis in trace amine-associated receptor 5 (TAAR5) knockout mice.
Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice.
Title: Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice.
TAAR3, TAAR4 and TAAR5 are evolutionarily conserved and determine the sensitivity to a class of biologically relevant chemicals
Title: Single olfactory receptors set odor detection thresholds.
In mouse, TAAR5 is encoded by adjacent genes and localize to adjacent glomeruli, yet mediate opposing behaviors.
Title: Trace amine-associated receptors: ligands, neural circuits, and behaviors.
Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
Title: A second class of chemosensory receptors in the olfactory epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Markers

Taar5 (e-PCR), detects polymorphism
- UniSTS:516839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables trimethylamine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables trimethylamine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables trimethylamine receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	TAS Traceable Author Statement more info	PubMed
involved_in sensory perception of chemical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in social behavior	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: trace amine-associated receptor 5

Names: mTaar5; trimethylamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.