SRSF10 serine and arginine rich splicing factor 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRSF10provided by HGNC
Official Full Name: serine and arginine rich splicing factor 10provided by HGNC
Primary source: HGNC:HGNC:16713
See related: Ensembl:ENSG00000188529 MIM:605221; AllianceGenome:HGNC:16713
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (23964347..23980327, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (23801766..23817752, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (24290837..24306817, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma.
Title: Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma.
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis.
Title: lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis.
SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis.
Title: SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis.
The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
Title: The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
Identification of SRSF10 as a regulator of SMN2 ISS-N1.
Title: Identification of SRSF10 as a regulator of SMN2 ISS-N1.
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
Title: Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.
Title: SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.
Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
Title: Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
Moreover, SRSF10, hnRNP A1/A2 and Sam68 collaborate to drive the DNA damage-induced splicing response of several transcripts that produce components implicated in apoptosis, cell-cycle control and DNA repair.
Title: hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage.
DNA damage co-opts SRSF10 to control splicing decisions in transcripts encoding components involved in DNA repair, cell-cycle control, and apoptosis.
Title: SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of serine/arginine-rich splicing factor 10 (SRSF10, FUSIP1) in the nucleoli of Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

D8S2279 (e-PCR)
- UniSTS:473907

D1S2514 (e-PCR)
- UniSTS:47156

D20S621 (e-PCR)
- UniSTS:63561

D22S1584 (e-PCR)
- UniSTS:473695

D15S1477 (e-PCR)
- UniSTS:474482

RH80030 (e-PCR)
- UniSTS:87680

D11S3114 (e-PCR)
- UniSTS:152207

Fusip1 (e-PCR), detects polymorphism
- UniSTS:525486

D22S296 (e-PCR)
- UniSTS:147641

GDB:335751 (e-PCR)
- UniSTS:156601

HUM00TW133 (e-PCR)
- UniSTS:17094

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables RS domain binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing, via transesterification reactions	IDA Inferred from Direct Assay more info	PubMed
involved_in cytosolic transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in spliceosomal tri-snRNP complex assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: serine/arginine-rich splicing factor 10

Names: 40 kDa SR-repressor protein; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; SR splicing factor 10; TLS-associated SR protein; TLS-associated protein TASR; TLS-associated protein with SR repeats; TLS-associated protein with Ser-Arg repeats; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; neural-salient SR protein; protein phosphatase 1, regulatory subunit 149; serine-arginine repressor protein (40 kDa); splicing factor SRp38; splicing factor, arginine/serine-rich 13; splicing factor, arginine/serine-rich 13A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191005.3 → NP_001177934.1 serine/arginine-rich splicing factor 10 isoform 3

See identical proteins and their annotated locations for NP_001177934.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (3) is shorter than isoform 2.

Source sequence(s)

AK001656, AL590609

Consensus CDS

CCDS53282.1

UniProtKB/TrEMBL

Q53GD7

Related

ENSP00000344149.4, ENST00000343255.9

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001191006.3 → NP_001177935.1 serine/arginine-rich splicing factor 10 isoform 4

See identical proteins and their annotated locations for NP_001177935.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AK093226, AL590609, BC010074

Consensus CDS

CCDS53283.1

UniProtKB/Swiss-Prot

O75494

Related

ENSP00000363576.5, ENST00000374452.9

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001191007.3 → NP_001177936.1 serine/arginine-rich splicing factor 10 isoform 5

See identical proteins and their annotated locations for NP_001177936.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AK093226, AL590609, AY007101

Consensus CDS

CCDS53281.1

UniProtKB/Swiss-Prot

O75494

Related

ENSP00000388991.3, ENST00000453840.7

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001191009.3 → NP_001177938.1 serine/arginine-rich splicing factor 10 isoform 6

See identical proteins and their annotated locations for NP_001177938.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (6) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AK296175, AL590609, AY007101

Consensus CDS

CCDS53280.1

UniProtKB/Swiss-Prot

O75494

Related

ENSP00000419813.2, ENST00000484146.6

Conserved Domains (1) summary

cd12559
Location:5 → 99

RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
NM_001300936.2 → NP_001287865.1 serine/arginine-rich splicing factor 10 isoform 8

See identical proteins and their annotated locations for NP_001287865.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (8) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AL590609

Consensus CDS

CCDS72728.1

UniProtKB/TrEMBL

Q5JRI1

Related

ENSP00000363577.3, ENST00000374453.7

Conserved Domains (1) summary

cl17169
Location:10 → 93

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001300937.2 → NP_001287866.1 serine/arginine-rich splicing factor 10 isoform 9

See identical proteins and their annotated locations for NP_001287866.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (9) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AL590609

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_006625.6 → NP_006616.1 serine/arginine-rich splicing factor 10 isoform 1

See identical proteins and their annotated locations for NP_006616.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AF419331, AL590609

Consensus CDS

CCDS30629.1

UniProtKB/Swiss-Prot

O75494

Related

ENSP00000342913.5, ENST00000344989.10

Conserved Domains (1) summary

cd12559
Location:5 → 99

RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
NM_054016.4 → NP_473357.1 serine/arginine-rich splicing factor 10 isoform 2

See identical proteins and their annotated locations for NP_473357.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AK093226, AL590609, BC005039

Consensus CDS

CCDS30630.1

UniProtKB/Swiss-Prot

A6NFM6, A6NI42, A6NIU7, B4DJP9, O60572, O75494, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4, Q96G09, Q96P17

UniProtKB/TrEMBL

A0A0S2Z504, Q53GD7

Related

ENSP00000420195.1, ENST00000492112.3

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily

RNA

NR_034035.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains multiple differences at both the 5' and 3' ends, compared to variant 2. This variant is represented as non-coding because the longest in-frame ORF does not meet RefSeq quality criteria.

Source sequence(s)

AK093226, AL590609, AY007101

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

23964347..23980327 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017000102.3 → XP_016855591.1 serine/arginine-rich splicing factor 10 isoform X1

UniProtKB/TrEMBL

B3KNY6

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

23801766..23817752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333940.1 → XP_054189915.1 serine/arginine-rich splicing factor 10 isoform X1

UniProtKB/TrEMBL

B3KNY6
XM_054333939.1 → XP_054189914.1 serine/arginine-rich splicing factor 10 isoform X1

UniProtKB/TrEMBL

B3KNY6