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    Ankrd26 ankyrin repeat domain 26 [ Mus musculus (house mouse) ]

    Gene ID: 232339, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ankrd26provided by MGI
    Official Full Name
    ankyrin repeat domain 26provided by MGI
    Primary source
    MGI:MGI:1917887
    See related
    Ensembl:ENSMUSG00000007827 AllianceGenome:MGI:1917887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1074; 5730521P14Rik
    Summary
    Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin cytoskeleton. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human ANKRD26 (ankyrin repeat domain containing 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 3.8) and 19 other tissues See more
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    Genomic context

    See Ankrd26 in Genome Data Viewer
    Location:
    6 F1; 6 55.86 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118478261..118539244, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118501300..118562280, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 248 pseudogene Neighboring gene zinc finger protein 9 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene predicted gene, 38887 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat domain-containing protein 26

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081112.2NP_001074581.1  ankyrin repeat domain-containing protein 26

      Status: VALIDATED

      Source sequence(s)
      AC036121, AC140192
      Consensus CDS
      CCDS39609.1
      UniProtKB/Swiss-Prot
      Q69ZS2, Q811D2, Q9CS61
      UniProtKB/TrEMBL
      D3Z482
      Related
      ENSMUSP00000108449.2, ENSMUST00000112830.3
      Conserved Domains (8) summary
      COG1340
      Location:11971457
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00204
      Location:75200
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12001
      Location:14951602
      DUF3496; Domain of unknown function (DUF3496)
      pfam12796
      Location:85177
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:51101
      Ank_4; Ankyrin repeats (many copies)
      pfam14915
      Location:8861189
      CCDC144C; CCDC144C protein coiled-coil region
      sd00045
      Location:82111
      ANK; ANK repeat [structural motif]
      cl21509
      Location:11951329
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      118478261..118539244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506023.4XP_006506086.1  ankyrin repeat domain-containing protein 26 isoform X2

      UniProtKB/Swiss-Prot
      Q69ZS2, Q811D2, Q9CS61
      Conserved Domains (6) summary
      PLN03192
      Location:54277
      PLN03192; Voltage-dependent potassium channel; Provisional
      COG1196
      Location:6901521
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:82111
      ANK; ANK repeat [structural motif]
      pfam12001
      Location:14621569
      DUF3496; Domain of unknown function (DUF3496)
      pfam12796
      Location:85177
      Ank_2; Ankyrin repeats (3 copies)
      pfam14915
      Location:8531156
      CCDC144C; CCDC144C protein coiled-coil region
    2. XM_006506022.4XP_006506085.1  ankyrin repeat domain-containing protein 26 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZS2, Q811D2, Q9CS61
      Conserved Domains (6) summary
      PLN03192
      Location:54277
      PLN03192; Voltage-dependent potassium channel; Provisional
      COG1196
      Location:7281559
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:82111
      ANK; ANK repeat [structural motif]
      pfam12001
      Location:15001607
      DUF3496; Domain of unknown function (DUF3496)
      pfam12796
      Location:85177
      Ank_2; Ankyrin repeats (3 copies)
      pfam14915
      Location:8911194
      CCDC144C; CCDC144C protein coiled-coil region
    3. XM_036166065.1XP_036021958.1  ankyrin repeat domain-containing protein 26 isoform X6

      Conserved Domains (3) summary
      COG1196
      Location:3051136
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12001
      Location:10771184
      DUF3496; Domain of unknown function (DUF3496)
      pfam14915
      Location:468772
      CCDC144C; CCDC144C protein coiled-coil region
    4. XM_036166064.1XP_036021957.1  ankyrin repeat domain-containing protein 26 isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:3381169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12001
      Location:11101217
      DUF3496; Domain of unknown function (DUF3496)
      pfam14915
      Location:501805
      CCDC144C; CCDC144C protein coiled-coil region
    5. XM_030255354.2XP_030111214.1  ankyrin repeat domain-containing protein 26 isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:3431174
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12001
      Location:11151222
      DUF3496; Domain of unknown function (DUF3496)
      pfam14915
      Location:506809
      CCDC144C; CCDC144C protein coiled-coil region
    6. XM_006506025.4XP_006506088.1  ankyrin repeat domain-containing protein 26 isoform X7

      Conserved Domains (3) summary
      COG1196
      Location:2401071
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12001
      Location:10121119
      DUF3496; Domain of unknown function (DUF3496)
      pfam14915
      Location:403706
      CCDC144C; CCDC144C protein coiled-coil region
    7. XM_006506024.4XP_006506087.1  ankyrin repeat domain-containing protein 26 isoform X3

      UniProtKB/Swiss-Prot
      Q69ZS2, Q811D2, Q9CS61
      Conserved Domains (6) summary
      PLN03192
      Location:54277
      PLN03192; Voltage-dependent potassium channel; Provisional
      COG1196
      Location:660930
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:11041300
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      sd00045
      Location:82111
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:85177
      Ank_2; Ankyrin repeats (3 copies)
      pfam14915
      Location:8911194
      CCDC144C; CCDC144C protein coiled-coil region

    RNA

    1. XR_001785122.3 RNA Sequence