U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Grxcr1 glutaredoxin, cysteine rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 433899, updated on 27-Nov-2024

    Summary

    Official Symbol
    Grxcr1provided by MGI
    Official Full Name
    glutaredoxin, cysteine rich 1provided by MGI
    Primary source
    MGI:MGI:3577767
    See related
    Ensembl:ENSMUSG00000068082 AllianceGenome:MGI:3577767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pi; tde; Tg(Eno2-Gabrb3)0370Brll
    Summary
    Involved in inner ear receptor cell stereocilium organization; sensory perception of sound; and vestibular receptor cell development. Acts upstream of or within cochlea development and inner ear auditory receptor cell differentiation. Located in kinocilium and stereocilium. Is expressed in endolymphatic duct; inner ear vestibular component; and utricle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Grxcr1 in Genome Data Viewer
    Location:
    5 C3.1; 5 36.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (68189122..68323741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (68031835..68166398)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930425K10 gene Neighboring gene predicted gene 15477 Neighboring gene predicted gene 5108 Neighboring gene STARR-seq mESC enhancer starr_13325 Neighboring gene STARR-seq mESC enhancer starr_13326 Neighboring gene STARR-seq mESC enhancer starr_13327 Neighboring gene STARR-seq mESC enhancer starr_13328 Neighboring gene predicted gene, 57742 Neighboring gene STARR-seq mESC enhancer starr_13329 Neighboring gene STARR-seq mESC enhancer starr_13330 Neighboring gene STARR-seq mESC enhancer starr_13331 Neighboring gene STARR-seq mESC enhancer starr_13332 Neighboring gene STARR-seq mESC enhancer starr_13333 Neighboring gene predicted gene, 23605

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Phenotypes

    Associated conditions

    Description Tests
    pirouette
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in kinocilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in stereocilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutaredoxin domain-containing cysteine-rich protein 1
    Names
    glutaredoxin cysteine-rich 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018019.3NP_001018019.3  glutaredoxin domain-containing cysteine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      AC107758, AC160555
      Consensus CDS
      CCDS19319.2
      UniProtKB/Swiss-Prot
      Q50H32
      UniProtKB/TrEMBL
      G3X9N2
      Related
      ENSMUSP00000092305.6, ENSMUST00000094715.9
      Conserved Domains (1) summary
      cd03031
      Location:138285
      GRX_GRX_like; Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      68189122..68323741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)