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    R3hdm2 R3H domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 71750, updated on 27-Nov-2024

    Summary

    Official Symbol
    R3hdm2provided by MGI
    Official Full Name
    R3H domain containing 2provided by MGI
    Primary source
    MGI:MGI:1919000
    See related
    Ensembl:ENSMUSG00000025404 AllianceGenome:MGI:1919000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1002; 1300003K24Rik
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. Is expressed in cortical plate; dorsal root ganglion; glossopharyngeal ganglion; trigeminal ganglion; and vagus ganglion. Orthologous to human R3HDM2 (R3H domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 25.1), frontal lobe adult (RPKM 22.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See R3hdm2 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127216201..127335253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127380332..127499384)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene inhibin beta-E Neighboring gene inhibin beta-C Neighboring gene predicted gene, 23819 Neighboring gene STARR-positive B cell enhancer mm9_chr10:126945421-126945721 Neighboring gene STARR-positive B cell enhancer ABC_E10656 Neighboring gene STARR-positive B cell enhancer ABC_E2342 Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene Ndufa4, mitochondrial complex associated like 2 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC144089

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    R3H domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168292.1NP_001161764.1  R3H domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001161764.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK043545, AK122416, BC053099, CJ078477
      Consensus CDS
      CCDS48717.1
      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Related
      ENSMUSP00000076303.6, ENSMUST00000077046.12
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    2. NM_001168293.1NP_001161765.1  R3H domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001161765.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK043545, BC053099, BC117927
      Consensus CDS
      CCDS48718.1
      UniProtKB/TrEMBL
      Q148X5
      Related
      ENSMUSP00000128659.2, ENSMUST00000170336.8
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:419768
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    3. NM_001359243.1NP_001346172.1  R3H domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK043545, BC043083, BC053099, CJ078477, CN531481, CX562801
      Consensus CDS
      CCDS48717.1
      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    4. NM_001359244.1NP_001346173.1  R3H domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK043545, BC043083, BC053099, CB527965, CJ078477, CN531481, CX562801
      Consensus CDS
      CCDS48718.1
      UniProtKB/TrEMBL
      Q148X5
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:419768
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    5. NM_001359245.1NP_001346174.1  R3H domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114678, AK043545, BC043083, BC053099, BY239444, CN531481
      Consensus CDS
      CCDS48718.1
      UniProtKB/TrEMBL
      Q148X5
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:419768
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    6. NM_001359246.1NP_001346175.1  R3H domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114678, AK043545, BC043083, BC053099
      Consensus CDS
      CCDS88102.1
      Related
      ENSMUSP00000100886.3, ENSMUST00000105251.9
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:433782
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    7. NM_027900.4NP_082176.4  R3H domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame exon, and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC114678, AK043545, BC053099
      Consensus CDS
      CCDS24241.1
      UniProtKB/Swiss-Prot
      Q80TM6
      Related
      ENSMUSP00000069724.7, ENSMUST00000064793.13
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:424820
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127216201..127335253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514153.2XP_006514216.1  R3H domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514216.1

      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    2. XM_006514162.4XP_006514225.1  R3H domain-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006514225.1

      UniProtKB/Swiss-Prot
      Q80TM6
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:431748
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    3. XM_006514160.3XP_006514223.1  R3H domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:449766
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    4. XM_006514158.3XP_006514221.1  R3H domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q80TM6
      Related
      ENSMUSP00000100885.3, ENSMUST00000105250.9
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:433782
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    5. XM_006514163.3XP_006514226.1  R3H domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      E9Q9D6
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:417734
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    6. XM_006514161.4XP_006514224.1  R3H domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:401750
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    7. XM_006514164.4XP_006514227.1  R3H domain-containing protein 2 isoform X8

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:399716
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    8. XM_036156025.1XP_036011918.1  R3H domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      Q5XKA9
      Conserved Domains (1) summary
      pfam09606
      Location:52341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    9. XM_006514154.5XP_006514217.1  R3H domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514217.1

      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    10. XM_036156023.1XP_036011916.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      Q148X5
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:419768
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    11. XM_030245292.2XP_030101152.1  R3H domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      E9Q9D6
      Related
      ENSMUSP00000131007.2, ENSMUST00000164831.8
      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:417734
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    12. XM_030245287.2XP_030101147.1  R3H domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:401750
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    13. XM_006514152.3XP_006514215.1  R3H domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514215.1

      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Related
      ENSMUSP00000126608.2, ENSMUST00000166820.8
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    14. XM_030245291.2XP_030101151.1  R3H domain-containing protein 2 isoform X6

      Related
      ENSMUSP00000100884.3, ENSMUST00000105249.9
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:431748
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    15. XM_030245293.1XP_030101153.1  R3H domain-containing protein 2 isoform X8

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:399716
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    16. XM_030245289.2XP_030101149.1  R3H domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:401750
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    17. XM_006514157.4XP_006514220.1  R3H domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514220.1

      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    18. XM_030245288.2XP_030101148.1  R3H domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:401750
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    19. XM_006514156.4XP_006514219.1  R3H domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514219.1

      UniProtKB/Swiss-Prot
      Q80TM6, Q80YB1, Q8BLS5, Q9CW50
      Conserved Domains (3) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:451800
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250303
      SUZ; SUZ domain
    20. XM_030245290.2XP_030101150.1  R3H domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      cd02642
      Location:168229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:401750
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    21. XM_036156024.1XP_036011917.1  R3H domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      Q5XKA9
      Conserved Domains (1) summary
      pfam09606
      Location:52341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    22. XM_030245294.1XP_030101154.1  R3H domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      Q5XKA9
      Conserved Domains (1) summary
      pfam09606
      Location:52341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    23. XM_030245295.2XP_030101155.1  R3H domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      Q5XKA9
      Conserved Domains (1) summary
      pfam09606
      Location:6288
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal