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    Fcgr2b Fc receptor, IgG, low affinity IIb [ Mus musculus (house mouse) ]

    Gene ID: 14130, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fcgr2bprovided by MGI
    Official Full Name
    Fc receptor, IgG, low affinity IIbprovided by MGI
    Primary source
    MGI:MGI:95499
    See related
    Ensembl:ENSMUSG00000026656 AllianceGenome:MGI:95499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik
    Summary
    Enables IgG binding activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; nervous system development; and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; liver; lung; and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc gamma receptor IIb). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 19.1), spleen adult (RPKM 16.7) and 21 other tissues See more
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    Genomic context

    See Fcgr2b in Genome Data Viewer
    Location:
    1 H3; 1 78.02 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170786186..170804141, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170960558..170976071, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Fc receptor-like A Neighboring gene STARR-positive B cell enhancer ABC_E5844 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9496 Neighboring gene predicted gene, 39701 Neighboring gene STARR-positive B cell enhancer ABC_E4384 Neighboring gene STARR-seq mESC enhancer starr_03000 Neighboring gene STARR-seq mESC enhancer starr_03002 Neighboring gene STARR-positive B cell enhancer ABC_E2584 Neighboring gene predicted gene, 34968 Neighboring gene predicted gene 10522

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IgG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables immunoglobulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-affinity IgG receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Fc receptor-mediated immune complex endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to amyloid-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune complex clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT acts_upstream_of_or_within mast cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of type I hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor II-b
    Names
    Fc gamma RIIB
    Fc-gamma-RII
    FcgammaRIIB
    fc gamma receptor IIB
    fc-gamma RII
    fc-gamma-RIIB
    igG Fc receptor II beta
    low affinity immunoglobulin gamma Fc region receptor II
    lymphocyte antigen 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077189.2NP_001070657.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

      See identical proteins and their annotated locations for NP_001070657.1

      Status: VALIDATED

      Source sequence(s)
      AC115959
      Consensus CDS
      CCDS35770.1
      UniProtKB/Swiss-Prot
      P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558
      UniProtKB/TrEMBL
      A0A0B4J1E6
      Related
      ENSMUSP00000027966.8, ENSMUST00000027966.14
      Conserved Domains (3) summary
      cd05753
      Location:128210
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:134210
      IG_like; Immunoglobulin like
      cl11960
      Location:46124
      Ig; Immunoglobulin domain
    2. NM_001419005.1NP_001405934.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115959
      UniProtKB/Swiss-Prot
      P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558
      UniProtKB/TrEMBL
      A0A0B4J1E6
      Related
      ENSMUSP00000137669.2, ENSMUST00000159969.8
    3. NM_001419006.1NP_001405935.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115959
      UniProtKB/Swiss-Prot
      P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558
    4. NM_001419007.1NP_001405936.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115959
      UniProtKB/Swiss-Prot
      P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558
      UniProtKB/TrEMBL
      E9Q415
      Related
      ENSMUSP00000123774.2, ENSMUST00000159688.2
    5. NM_001419008.1NP_001405937.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115959
      UniProtKB/Swiss-Prot
      P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558
    6. NM_001419009.1NP_001405938.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC115959
    7. NM_001419010.1NP_001405939.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115959
    8. NM_001419011.1NP_001405940.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC115959
    9. NM_010187.3NP_034317.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

      See identical proteins and their annotated locations for NP_034317.1

      Status: VALIDATED

      Source sequence(s)
      AC115959
      Consensus CDS
      CCDS35769.1
      UniProtKB/Swiss-Prot
      P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558
      UniProtKB/TrEMBL
      A0A0B4J1G1
      Related
      ENSMUSP00000079882.6, ENSMUST00000081103.12
      Conserved Domains (2) summary
      smart00410
      Location:134210
      IG_like; Immunoglobulin like
      cl11960
      Location:128210
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170786186..170804141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)